G
Gustavo Leone
Researcher at Medical University of South Carolina
Publications - 188
Citations - 16866
Gustavo Leone is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: E2F & Cell cycle. The author has an hindex of 64, co-authored 177 publications receiving 15152 citations. Previous affiliations of Gustavo Leone include University of Calgary & Duke University.
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Journal ArticleDOI
Emerging roles of E2Fs in cancer: an exit from cell cycle control
TL;DR: It is proposed that there are alternative tumour-promoting activities for the E2F family, which are independent of cell cycle regulation.
Journal ArticleDOI
Distinct roles for E2F proteins in cell growth control and apoptosis
TL;DR: It is concluded that E 2F family members play distinct roles in cell cycle control and that E2F1 may function as a specific signal for the initiation of an apoptosis pathway that must normally be blocked for a productive proliferation event.
Journal ArticleDOI
The E2F1–3 transcription factors are essential for cellular proliferation
Lizhao Wu,Cynthia Timmers,Baidehi Maiti,Harold I. Saavedra,Ling Sang,Gabriel T. Chong,Faison Nuckolls,Paloma H. Giangrande,Fred A. Wright,Seth J. Field,Michael E. Greenberg,Stuart H. Orkin,Joseph R. Nevins,Michael L. Robinson,Gustavo Leone +14 more
TL;DR: By targeting the entire subclass of E2F transcriptional activators, direct genetic evidence for their essential role in cell cycle progression, proliferation and development is provided.
Journal ArticleDOI
Role for E2F in Control of Both DNA Replication and Mitotic Functions as Revealed from DNA Microarray Analysis
Seiichi Ishida,Erich Huang,Harry Zuzan,Rainer Spang,Gustavo Leone,Mike West,Joseph R. Nevins +6 more
TL;DR: High-density DNA microarrays used to provide an analysis of gene regulation during the mammalian cell cycle and the role of E2F in this process identified genes or expressed sequence tags not previously described as regulated by E1F proteins; surprisingly, many of these encode proteins known to function during mitosis.
Journal ArticleDOI
Pten in stromal fibroblasts suppresses mammary epithelial tumours
Anthony J. Trimboli,Carmen Z. Cantemir-Stone,Fu Li,Julie A. Wallace,Anand S. Merchant,Nicholas Creasap,John C. Thompson,Enrico Caserta,Hui Wang,Jean-Leon Chong,Shan Naidu,Guo Wei,Sudarshana M. Sharma,Julie A. Stephens,Soledad Fernandez,Metin N. Gurcan,Michael Weinstein,Sanford H. Barsky,Lisa D. Yee,Thomas J. Rosol,Paul C. Stromberg,Michael L. Robinson,Francois Pepin,Michael Hallett,Morag Park,Michael C. Ostrowski,Gustavo Leone,Gustavo Leone +27 more
TL;DR: The Pten–Ets2 axis is identified as a critical stroma-specific signalling pathway that suppresses mammary epithelial tumours and ameliorated disruption of the tumour microenvironment.