Journal ArticleDOI
Protein Modification by Methylglyoxal: Chemical Nature and Synthetic Mechanism of a Major Fluorescent Adduct
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TLDR
It is indicated that argpyrimidine is synthesized through an intermediate 3-hydroxypentane-2,4-dione and provide a chemical basis for fluorescence in proteins modified by methylglyoxal, suggesting that it is a major product in such modified proteins.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 1997-08-01. It has received 270 citations till now. The article focuses on the topics: Methylglyoxal & Maillard reaction.read more
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Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus
TL;DR: A review will highlight the involvement of AGEs in the development and progression of T2DM and their role in diabetic complications and the role of oxidative stress in hyperglycemia-induced tissue injury.
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Mechanisms of maturation and ageing of collagen
TL;DR: An understanding of these mechanisms is now leading to the development of inhibitors of glycation and compounds capable of cleaving the cross-links, thus alleviating the devastating effects of ageing.
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Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): An overview of their mechanisms of formation
TL;DR: The aim of the present review is to group the main AGEs and ALEs and to describe, for each of them, the precursors and mechanisms of formation.
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Role of reactive aldehyde in cardiovascular diseases.
TL;DR: The protein-bound aldehydes can be detected as constituents not only in in vitro oxidized low-density lipoproteins but also in animal models of atherosclerosis and in human patients with increased risk factors or clinical manifestations of Atherosclerosis, indicating that they could indeed be involved in the caldiovascular pathology.
Journal ArticleDOI
Glycoxidation and lipoxidation in atherogenesis.
John W. Baynes,Suzanne R. Thorpe +1 more
TL;DR: Nucleophilic AGE-inhibitors, such as aminoguanidine and pyridoxamine, which trap reactive carbonyls and inhibit the formation of AGEs in diabetes, also trap bioactive lipids and precursors of ALEs in atherosclerosis.
References
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Purification of laboratory chemicals
TL;DR: Common physical techniques used in purification chemical methods used in Purification purification of organic chemicals Purification of inorganic and metal organic chemicals general methods for the purification classification of classes of compounds and natural products biochemicals and related products as mentioned in this paper.
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Role of Oxidative Stress in Development of Complications in Diabetes
TL;DR: Structural characterization of the cross-links and other products accumulating in collagen in diabetes is needed to gain a better understanding of the relationship between oxidative stress and the development of complications in diabetes.
Journal ArticleDOI
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
Shi Du Yan,Xi Chen,Jin Fu,Ming Chen,Huaijie Zhu,Alex E. Roher,Timothy Slattery,Lei Zhao,Mariko Nagashima,John Morser,Antonio Migheli,Peter P. Nawroth,David I. Stern,Ann Marie Schmidt +13 more
TL;DR: Evidence is presented that the 'receptor for advanced glycation end products' (RAGE) is such a receptor, and that it mediates effects of the peptide on neurons and microglia and indicates that it is relevant to the pathogenesis of neuronal dysfunction and death.
Journal ArticleDOI
Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins.
Shi Du Yan,Ann Marie Schmidt,G. M. Anderson,Jinghua Zhang,J Brett,Yu Shan Zou,David J. Pinsky,David M. Stern +7 more
TL;DR: Data indicate that interaction of AGEs with cellular targets, such as ECs, leads to oxidant stress resulting in changes in gene expression and other cellular properties, potentially contributing to the development of vascular lesions.
Journal ArticleDOI
Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.
Ann Marie Schmidt,Osamu Hori,Jing Xian Chen,Jianfeng Li,Jill P. Crandall,Jinghua Zhang,Rong Cao,Shirley ShiDu Yan,Jerold Brett,David M. Stern +9 more
TL;DR: Data are consistent with the hypothesis that AGE-RAGE interaction induces expression of VCAM-1 which can prime diabetic vasculature for enhanced interaction with circulating monocytes.
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