R
Rami I. Aqeilan
Researcher at Hebrew University of Jerusalem
Publications - 152
Citations - 14107
Rami I. Aqeilan is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: WWOX & WW domain. The author has an hindex of 51, co-authored 144 publications receiving 13034 citations. Previous affiliations of Rami I. Aqeilan include Thomas Jefferson University & Ohio State University.
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Erratum: miR-15 and miR-16 induce apoptosis by targeting BCL2 (Proceedings of the National Academy of Sciences of the United States of America (September 27, 2005) 102, 39 (13944-13949) DOI: 10.1073/pnas.0506654102)
Amelia Cimmino,George A. Calin,Muller Fabbri,Marilena V. Iorio,Manuela Ferracin,Masayoshi Shimizu,Sylwia E. Wojcik,Rami I. Aqeilan,Simona Zupo,Mariella Dono,Laura Z. Rassenti,Hansjuerg Alder,Stefano Volinia,Chang Gong Liu,Thomas J. Kipps,Massimo Negrini,Carlo M. Croce +16 more
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Effect of Rapamycin on Mouse Chronic Lymphocytic Leukemia and the Development of Nonhematopoietic Malignancies in Eμ-TCL1 Transgenic Mice
Nicola Zanesi,Rami I. Aqeilan,Alessandra Drusco,Mohamed Kaou,Cinzia Sevignani,Stefan Costinean,Laura Bortesi,Laura Bortesi,Gaspare La Rocca,Pavel Koldovsky,Stefano Volinia,Rita Mancini,Rita Mancini,George A. Calin,Charles P. Scott,Yuri Pekarsky,Carlo M. Croce +16 more
TL;DR: Findings indicate that other oncogenic mechanism(s) may be involved in the development of solid tumors in Emu-TCL1 transgenic mice by testing the ability of a specific pharmacologic agent, rapamycin, to slow CLL.
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Inactivation of the Wwox Gene Accelerates Forestomach Tumor Progression In vivo
Rami I. Aqeilan,John P. Hagan,Haifa A. Aqeilan,Flavia Pichiorri,Louise Y.Y. Fong,Carlo M. Croce +5 more
TL;DR: These findings provide the first in vivo evidence of the tumor suppressor function of WWOX in forestomach/esophageal carcinogenesis and suggest that inactivation of one allele of WWox accelerates the predisposition of normal cells to malignant transformation.
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Fhit is a physiological target of the protein kinase Src.
Yuri Pekarsky,P.N. Garrison,Alexey Palamarchuk,Nicola Zanesi,Rami I. Aqeilan,Kay Huebner,Larry D. Barnes,Carlo M. Croce +7 more
TL;DR: It is demonstrated that Fhit is a target of tyrosine phosphorylation by the Src protein kinase in vitro and in vivo, providing insight into a biochemical pathway involved in Fhit signaling.
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NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation.
TL;DR: NEDD4 acts as an additional regulator of the Hippo pathway on the protein level via interactions between WW domain-containing and PPxY motif-containing proteins, and it is proved that NEDD 4 E3 ubiquitin ligase controls LATS1 stability.