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Alexey Palamarchuk
Researcher at Ohio State University
Publications - 31
Citations - 2536
Alexey Palamarchuk is an academic researcher from Ohio State University. The author has contributed to research in topics: Chronic lymphocytic leukemia & Leukemia. The author has an hindex of 23, co-authored 30 publications receiving 2226 citations. Previous affiliations of Alexey Palamarchuk include Thomas Jefferson University.
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Journal ArticleDOI
Functional association between Wwox tumor suppressor protein and p73, a p53 homolog
Rami I. Aqeilan,Yuri Pekarsky,Juan J. Herrero,Alexey Palamarchuk,Jean Letofsky,Teresa Druck,Francesco Trapasso,Shuang Yin Han,Gerry Melino,Kay Huebner,Carlo M. Croce +10 more
TL;DR: The WWOX gene is a recently cloned tumor suppressor gene that spans the FRA16D fragile region and it is demonstrated that Wwox expression triggers redistribution of nuclear p73 to the cytoplasm and, hence, suppresses its transcriptional activity.
Journal ArticleDOI
WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function.
Rami I. Aqeilan,Valentina Donati,Alexey Palamarchuk,Francesco Trapasso,Mohamed Kaou,Yuri Pekarsky,Marius Sudol,Carlo M. Croce +7 more
TL;DR: The data indicate that WWOX antagonizes the function of YAP by competing for interaction with ErbB-4 and other targets and thus affect its transcriptional activity.
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NOTCH1 mutations in CLL associated with trisomy 12
Veronica Balatti,Arianna Bottoni,Alexey Palamarchuk,Hansjuerg Alder,Laura Z. Rassenti,Thomas J. Kipps,Yuri Pekarsky,Carlo M. Croce +7 more
TL;DR: In this paper, the results of sequencing of XPO1 and NOTCH1 in 186 CLL cases were reported, and the results confirmed frequency of notch1 mutations in 2.4% of cases, while notCH1 was found mutated in 12.2% or 15.1% of CLL samples.
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tsRNA signatures in cancer.
Veronica Balatti,Giovanni Nigita,Dario Veneziano,Alessandra Drusco,Gary S. Stein,Terri L. Messier,Nicholas H. Farina,Jane B. Lian,Luisa Tomasello,Chang Gong Liu,Alexey Palamarchuk,Jonathan R. Hart,Catherine M Bell,Mariantonia Carosi,Edoardo Pescarmona,Letizia Perracchio,Maria Grazia Diodoro,Andrea Russo,Anna Antenucci,Paolo Visca,Antonio Ciardi,Curtis C. Harris,Peter K. Vogt,Yuri Pekarsky,Carlo M. Croce +24 more
TL;DR: It is found that tRNA-derived small RNAs (tsRNAs) are dysregulated in many cancers and that their expression is modulated during cancer development and staging, and tsRNA-KO cells display a specific change in gene-expression profile, suggesting tsRNAs could be key effectors in cancer-related pathways.
Journal ArticleDOI
Dysregulation of a family of short noncoding RNAs, tsRNAs, in human cancer.
Yuri Pekarsky,Veronica Balatti,Alexey Palamarchuk,Lara Rizzotto,Dario Veneziano,Giovanni Nigita,Laura Z. Rassenti,Harvey I. Pass,Thomas J. Kipps,Chang Gong Liu,Carlo M. Croce +10 more
TL;DR: The results show that tsRNAs are dysregulated in human cancer.