Ramon Cueto

TL;DR: This article intensively reviewed and refined biochemical basis, metabolic signaling and regulation, functional insights, and provided guidance for the identification of novel therapeutic targets.

TL;DR: This chapter briefly addresses the recent progress made in understanding the role of proton leak in the pathogenesis of cardiovascular diseases, and surmises the roles of "uncoupling" in cardiovascular disorders.

TL;DR: The importance of Tregs in many autoimmune diseases and experimental atherosclerosis has been established in in vivo and in vitro studies, however, the roles in the clinical setting remains to be further characterized.

TL;DR: A new paradigm that most nuclear receptors are anti-inflammatory homeostasis-associated molecular pattern receptors (HAMPRs) is proposed to provide a novel insight on NRs as therapeutic targets in metabolic diseases, inflammations, and malignancies.

TL;DR: Inhibition of caspase-1 improves VEGFR-2 signaling, tube formation, and blood perfusion in ischemic tissues, and demonstrates for the first time that inhibition of proatherogenic casp enzyme-1 activation in ECs improves angiogenesis and the prognosis of ischemia.