Xinyuan Li

TL;DR: Recent understanding of how mitochondria generate and regulate the production ofmtROS and the function of mtROS both in physiological and pathological conditions are updated and newly developed methods to probe or scavenge mtR OS are described.

TL;DR: In-depth analyses of molecular events that regulate the production of IL-35 as well as the new categorization system of anti-inflammatory cytokines are important for the design of new strategies of immune therapies.

TL;DR: The results indicate that mitochondrial antioxidants are promising therapies for vascular inflammation and cardiovascular diseases.

TL;DR: It is demonstrated for the first time that early hyperlipidemia promotes EC activation before monocyte recruitment via a caspase-1–sirtuin 1–activator protein-1 pathway, which provides an important insight into the development of novel therapeutics for blocking caspasing-1 activation as early intervention of metabolic cardiovascular diseases and inflammations.

TL;DR: Understanding of the distinct molecular mechanism by which metabolic ligands activates inflammasome could lead to developing novel therapeutic interventions for atherosclerosis and other clinical problems related to metabolic diseases.