Ya-Feng Li

TL;DR: A circulating miRNA profile for hypertensive patients is reported for the first time and a novel link between HCMV infection and essential hypertension is demonstrated to reveal important insights into the pathogenesis of essential hypertension.

TL;DR: The results indicate that mitochondrial antioxidants are promising therapies for vascular inflammation and cardiovascular diseases.

TL;DR: It is demonstrated for the first time that early hyperlipidemia promotes EC activation before monocyte recruitment via a caspase-1–sirtuin 1–activator protein-1 pathway, which provides an important insight into the development of novel therapeutics for blocking caspasing-1 activation as early intervention of metabolic cardiovascular diseases and inflammations.

TL;DR: A new paradigm that most nuclear receptors are anti-inflammatory homeostasis-associated molecular pattern receptors (HAMPRs) is proposed to provide a novel insight on NRs as therapeutic targets in metabolic diseases, inflammations, and malignancies.

TL;DR: MicroRNA-21 (miR-21) is a recently identified, typical miRNA that is functional as a regulator known to be involved in apoptosis as well as inflammatory and fibrotic signaling pathways in AKI, and is now considered a novel biomarker when diagnosing and treating AKI.