Showing papers by "Ranjan Deka published in 2001"
Fudan University1, University of Texas Health Science Center at Houston2, Kunming Institute of Zoology3, Eijkman Institute for Molecular Biology4, University of Cincinnati5, Stanford University6, Yunnan University7, Pennsylvania State University8, Emory University9, University of Oxford10, Harvard University11
TL;DR: The data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia and coalesce to another mutation which originated in Africa about 35,000 to 89,000 years ago.
Abstract: To test the hypotheses of modern human origin in East Asia, we sampled 12,127 male individuals from 163 populations and typed for three Y chromosome biallelic markers (YAP, M89, and M130). All the individuals carried a mutation at one of the three sites. These three mutations (YAP+, M89T, and M130T) coalesce to another mutation (M168T), which originated in Africa about 35,000 to 89,000 years ago. Therefore, the data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia.
217 citations
TL;DR: This study failed to detect any association between case subjects and control subjects in allele frequencies, haplotype frequencies, or haplotype combinations of UCSNP43, -19, and -63, and showed no evidence of linkage, among 201 affected sib pairs, in the region of chromosome 2 that contains these SNPs.
Abstract: Although genomewide scans have identified several potential chromosomal susceptibility regions in several human populations, finding a causative gene for type 2 diabetes has remained elusive. Others have reported a novel gene, calpain-10 (CAPN10), located in a previously identified region on chromosome 2q37.3, as a putative susceptibility gene for type 2 diabetes. Three single-nucleotide polymorphisms (SNPs) (UCSNP43, UCSNP19, and UCSNP63) were shown to be involved in increased risk of the disease among Mexican Americans. We have tested the association of these three SNPs with type 2 diabetes among the Samoans of Polynesia, who have a very high prevalence of the disease. In the U.S. territory of American Samoa, prevalence is 25% and 15% in men and women, respectively, whereas, in the independent nation of Samoa, prevalence is 3% and 5% in men and women, respectively. In our study sample, which consisted of 172 unrelated affected case subjects and 96 control subjects, we failed to detect any association between case subjects and control subjects in allele frequencies, haplotype frequencies, or haplotype combinations of UCSNP43, -19, and -63. Also, our data showed no evidence of linkage, among 201 affected sib pairs, in the region of chromosome 2 that contains these SNPs. Three plausible scenarios could explain these observations. (1) CAPN10 is a susceptibility gene only in particular ethnic groups; (2) our study lacks power to detect the effects of CAPN10 polymorphisms (but our sample size is comparable to that of earlier reports); or (3) the underlying biological mechanism is too complex and requires further research.
100 citations
TL;DR: It is claimed that these hypervariable markers are quite useful in understanding the process of substructuring within the Indian castes, leading to the formation of smaller breeding isolates, the basic Mendelian units within which microevolutionary forces operate.
Abstract: This is the publisher's version, also available electronically from http://digitalcommons.wayne.edu/humbiol/vol73/iss2/2/
33 citations
TL;DR: STR Data for the Amp FlSTR Profiler Plus Loci Among Golla Population of Southern Andhra Pradesh, India shows that the Golla population is more mobile than the rest of the state, and the number of mobile homes is higher than the other states.
Abstract: STR Data for the Amp FlSTR Profiler Plus Loci Among Golla Population of Southern Andhra Pradesh, India
15 citations