R
Ranjit K. Thirumaran
Researcher at St. Jude Children's Research Hospital
Publications - 28
Citations - 1380
Ranjit K. Thirumaran is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Single-nucleotide polymorphism & Odds ratio. The author has an hindex of 20, co-authored 27 publications receiving 1245 citations. Previous affiliations of Ranjit K. Thirumaran include German Cancer Research Center.
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Journal ArticleDOI
Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms.
Anna-Lena Lindberg,Rajesh Kumar,Walter Goessler,Ranjit K. Thirumaran,Eugen Gurzau,Kvetoslava Koppova,Peter Rudnai,Giovanni Leonardi,Tony Fletcher,Marie Vahter +9 more
TL;DR: The results show that the M287T (T→C) polymorphism in the AS3MT gene, the A222V (C→T) polymorphisms in the MTHFR gene, body mass index, and sex are major factors that influence arsenic metabolism in this population, with a median of 8.0 μg/L arsenic in urine.
Journal ArticleDOI
Pharmacogenetic Allele Nomenclature: International Workgroup Recommendations for Test Result Reporting
Lisa V. Kalman,Jag Agúndez,M Lindqvist Appell,John L. Black,Gillian C. Bell,Sotiria Boukouvala,C Bruckner,Elspeth A. Bruford,Kelly E. Caudle,Sally A. Coulthard,Ann K. Daly,AL Del Tredici,JT den Dunnen,Katarzyna Drozda,Robin E. Everts,David A. Flockhart,Robert R. Freimuth,A. Gaedigk,H Hachad,Toinette Hartshorne,Magnus Ingelman-Sundberg,Teri E. Klein,Volker M. Lauschke,Maglott,Howard L. McLeod,Gwendolyn A. McMillin,Urs A. Meyer,Daniel J. Müller,Deborah A. Nickerson,William S. Oetting,Michael Pacanowski,Victoria M. Pratt,Mary V. Relling,A Roberts,Wendy S. Rubinstein,Katrin Sangkuhl,Matthias Schwab,Stuart A. Scott,Sarah C. Sim,Ranjit K. Thirumaran,Lorraine Toji,Rachel F. Tyndale,Rhn van Schaik,Michelle Whirl-Carrillo,Ktj Yeo,Ulrich M. Zanger +45 more
TL;DR: This article provides nomenclature recommendations developed by an international workgroup to increase transparency and standardization of pharmacogenetic (PGx) result reporting.
Journal ArticleDOI
B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis.
Selma Ugurel,Ranjit K. Thirumaran,Sandra Bloethner,Andreas Gast,Antje Sucker,Jan Mueller-Berghaus,Werner Rittgen,Kari Hemminki,Kari Hemminki,Jürgen C. Becker,Rajesh Kumar,Rajesh Kumar,Dirk Schadendorf +12 more
TL;DR: It is demonstrated that B-RAF and N-RAS mutations are well preserved during short term in vitro propagation and, most importantly, differentially impact the outcome of melanoma patients.
Journal ArticleDOI
Clinical impact of pharmacogenetic profiling with a clinical decision support tool in polypharmacy home health patients: A prospective pilot randomized controlled trial.
Lindsay S. Elliott,John Henderson,Moni B. Neradilek,Nicolas A. Moyer,Kristine C. Ashcraft,Ranjit K. Thirumaran +5 more
TL;DR: Pharmacogenetic testing of polypharmacy patients aged 50 and older, supported by an appropriate CDST, considerably reduced re-hospitalizations and ED visits at 60 days following enrollment resulting in potential health resource utilization savings and improved healthcare.
Journal ArticleDOI
Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers.
TL;DR: The results show that the genetic variation in XR CC1, XRCC3 and NBS1 influence lung cancer susceptibility among women, and that combinations of risk alleles in the two HR genes can enhance the effects.