K
Kari Hemminki
Researcher at Charles University in Prague
Publications - 1324
Citations - 60117
Kari Hemminki is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Cancer & Population. The author has an hindex of 100, co-authored 1274 publications receiving 55290 citations. Previous affiliations of Kari Hemminki include Lund University & Novum.
Papers
More filters
Journal ArticleDOI
Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland
Paul Lichtenstein,Niels V. Holm,Pia K. Verkasalo,Anastasia Iliadou,Jaakko Kaprio,Jaakko Kaprio,Markku Koskenvuo,Markku Koskenvuo,Eero Pukkala,Axel Skytthe,Kari Hemminki +10 more
TL;DR: Inherited genetic factors make a minor contribution to susceptibility to most types of neoplasms, which indicates that the environment has the principal role in causing sporadic cancer.
Journal ArticleDOI
TERT Promoter Mutations in Familial and Sporadic Melanoma
Susanne Horn,Adina Figl,P. Sivaramakrishna Rachakonda,Christine Fischer,Antje Sucker,Andreas Gast,Stephanie Kadel,Iris Moll,Eduardo Nagore,Kari Hemminki,Kari Hemminki,Dirk Schadendorf,Rajesh Kumar +12 more
TL;DR: A melanoma-prone family through linkage analysis and high-throughput sequencing was investigated and a disease-segregating germline mutation in the promoter of the telomerase reverse transcriptase (TERT) gene, which encodes the catalytic subunit of telomersase, caused up to twofold increase in transcription.
Journal ArticleDOI
Genome-wide association study identifies five susceptibility loci for glioma
Sanjay Shete,Fay J. Hosking,Lindsay B. Robertson,Sara E. Dobbins,Marc Sanson,Beatrice Malmer,Matthias Simon,Yannick Marie,Blandine Boisselier,Jean Yves Delattre,Khê Hoang-Xuan,Soufiane El Hallani,Ahmed Idbaih,Diana Zelenika,Ulrika Andersson,Roger Henriksson,A. Tommy Bergenheim,Maria Feychting,Stefan Lönn,Anders Ahlbom,Johannes Schramm,Michael Linnebank,Kari Hemminki,Rajesh Kumar,S. J. Hepworth,Amy Price,Georgina Armstrong,Yanhong Liu,Xiangjun Gu,Robert Yu,Ching C. Lau,Minouk J. Schoemaker,Kenneth Muir,Anthony J. Swerdlow,Mark Lathrop,Melissa L. Bondy,Richard S. Houlston +36 more
TL;DR: Meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs shows that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.
Journal ArticleDOI
IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans
Richard J. Albertini,Diana Anderson,George R. Douglas,Lars Hagmar,Kari Hemminki,Franco Merlo,Adayapalam T. Natarajan,Hannu Norppa,David E. G. Shuker,Raymond R. Tice,Michael D. Waters,Antero Aitio +11 more
TL;DR: The most commonly studied genotoxicity endpoints have been selected for inclusion in this document and they are structural and numerical chromosomal aberrations assessed using cytogenetic methods (classical chromosomal aberration analysis (CA), fluorescence in situ hybridisation (FISH), micronuclei (MN), DNA damage (adducts, strand breaks, crosslinking, alkali-labile sites) assessed using bio-chemical/electrophoretic assays or sister chromatid exchanges (SCE); protein adducts; and hypoxanthine-
Journal ArticleDOI
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types.
Thorunn Rafnar,Patrick Sulem,Simon N. Stacey,Frank Geller,Julius Gudmundsson,Asgeir Sigurdsson,Margret Jakobsdottir,Hafdis T. Helgadottir,Steinunn Thorlacius,Katja K H Aben,Thorarinn Blondal,Thorgeir E. Thorgeirsson,Gudmar Thorleifsson,Kristleifur Kristjansson,Kristin Thorisdottir,Rafn Ragnarsson,Bardur Sigurgeirsson,Halla Skuladottir,Tomas Gudbjartsson,Helgi J Isaksson,Gudmundur V. Einarsson,Kristrun R. Benediktsdottir,Bjarni A. Agnarsson,Karl Olafsson,Anna Salvarsdottir,Hjordis Bjarnason,Margret Asgeirsdottir,Kari T. Kristinsson,Sigurborg Matthiasdottir,Steinunn G Sveinsdottir,Silvia Polidoro,Veronica Höiom,Rafael Botella-Estrada,Kari Hemminki,Peter Rudnai,D. Timothy Bishop,Marcello Campagna,Eliane Kellen,Maurice P. Zeegers,Maurice P. Zeegers,Petra J. de Verdier,Ana Ferrer,Dolores Isla,Maria Vidal,Raquel Andrés,Berta Saez,Pablo Juberías,Javier Banzo,Sebastian Navarrete,Alejandro Tres,Donghui Kan,Annika Lindblom,Eugene Gurzau,Kvetoslava Koppova,Femmie de Vegt,Jack A. Schalken,Henricus F. M. van der Heijden,Hans J Smit,René A Termeer,Egbert Oosterwijk,Onno van Hooij,Eduardo Nagore,Stefano Porru,Gunnar Steineck,Gunnar Steineck,Johan Hansson,Frank Buntinx,Frank Buntinx,William J. Catalona,Giuseppe Matullo,Paolo Vineis,Anne E. Kiltie,Jose I. Mayordomo,Rajesh Kumar,Lambertus A. Kiemeney,Michael L. Frigge,Thorvaldur Jonsson,Hafsteinn Saemundsson,Rosa B. Barkardottir,Eirikur Jonsson,Steinn Jonsson,Jón Ólafsson,Jeffrey R. Gulcher,Gisli Masson,Daniel F. Gudbjartsson,Augustine Kong,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +89 more
TL;DR: It is found that rs401681[C] on chromosome 5p15 satisfied the threshold for genome-wide significance and seems to confer protection against cutaneous melanoma, and investigation of the region led to rs2736098[A], which showed stronger association with some cancer types, but neither variant could fully account for the association of the other.