R
Raquel Salvador-Gallego
Researcher at University of Tübingen
Publications - 4
Citations - 481
Raquel Salvador-Gallego is an academic researcher from University of Tübingen. The author has contributed to research in topics: Mitochondrial apoptosis-induced channel & Bcl-2-associated X protein. The author has an hindex of 3, co-authored 3 publications receiving 350 citations. Previous affiliations of Raquel Salvador-Gallego include German Cancer Research Center & Max Planck Society.
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Journal ArticleDOI
Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores.
Raquel Salvador-Gallego,Raquel Salvador-Gallego,Markus Mund,Katia Cosentino,Katia Cosentino,Jale Schneider,Joseph D. Unsay,Joseph D. Unsay,Ulrich Schraermeyer,Johann Engelhardt,Jonas Ries,Ana J. García-Sáez,Ana J. García-Sáez +12 more
TL;DR: The data identify the supramolecular organization of Bax during apoptosis and support a molecular mechanism in which Bax fully or partially delineates pores of different sizes to permeabilize the mitochondrial outer membrane.
Journal ArticleDOI
Structural Model of Active Bax at the Membrane
Stephanie Bleicken,Gunnar Jeschke,Carolin Stegmueller,Carolin Stegmueller,Carolin Stegmueller,Raquel Salvador-Gallego,Raquel Salvador-Gallego,Raquel Salvador-Gallego,Ana J. García-Sáez,Ana J. García-Sáez,Ana J. García-Sáez,Enrica Bordignon,Enrica Bordignon +12 more
TL;DR: It is shown that active Bax is organized at the membrane as assemblies of dimers, and each monomer contains a more flexible piercing domain involved in interdimer interactions and pore formation.
Journal ArticleDOI
DRP1 interacts directly with BAX to induce its activation and apoptosis
Andreas Jenner,Aida Peña-Blanco,Raquel Salvador-Gallego,Begoña Ugarte-Uribe,Cris Zollo,Tariq Ganief,Jan Bierlmeier,Marcus Mund,Jason E. Lee,Jonas Ries,Dirk Schwarzer,Boris Macek,Ana J. García-Sáez +12 more
TL;DR: It is proposed that DRP1 can promote apoptosis by acting as noncanonical direct activator of BAX through physical contacts with its N‐terminal region.
Journal ArticleDOI
Systems-level effects of ectopic galectin-7 reconstitution in cervical cancer and its microenvironment
Juan Carlos Higareda-Almaraz,Juan Sebastian Ruiz-Moreno,Juan Sebastian Ruiz-Moreno,Jana Klimentova,Daniela Barbieri,Raquel Salvador-Gallego,Raquel Salvador-Gallego,Regina Ly,Ilse A. Valtierra-Gutiérrez,Christiane Dinsart,Gabriel A. Rabinovich,Jiri Stulik,Frank Rösl,Bladimiro Rincon-Orozco,Bladimiro Rincon-Orozco +14 more
TL;DR: Gal-7 re-expression affects the regulation of molecular networks in cervical cancer that are involved in diverse cancer hallmarks, such as metabolism, growth control, invasion and evasion of apoptosis, where networks involved in its configuration and in immune surveillance are particularly affected.