B
Boris Macek
Researcher at University of Tübingen
Publications - 226
Citations - 17136
Boris Macek is an academic researcher from University of Tübingen. The author has contributed to research in topics: Phosphorylation & Proteome. The author has an hindex of 53, co-authored 200 publications receiving 15135 citations. Previous affiliations of Boris Macek include University of Southern Denmark & University of Münster.
Papers
More filters
Journal ArticleDOI
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Jesper V. Olsen,Blagoy Blagoev,Florian Gnad,Boris Macek,Boris Macek,Chanchal Kumar,Peter Mortensen,Matthias Mann +7 more
TL;DR: A general mass spectrometric technology is developed and applied for identification and quantitation of phosphorylation sites as a function of stimulus, time, and subcellular location to provide a missing link in a global, integrative view of cellular regulation.
Journal ArticleDOI
Parts per Million Mass Accuracy on an Orbitrap Mass Spectrometer via Lock Mass Injection into a C-trap
Jesper V. Olsen,Jesper V. Olsen,Lyris M. F. de Godoy,Guoqing Li,Guoqing Li,Boris Macek,Peter Mortensen,Reinhold Pesch,Alexander Makarov,Oliver Lange,Stevan Horning,Matthias Mann,Matthias Mann +12 more
TL;DR: This work demonstrates sub-ppm mass accuracy on a linear ion trap coupled via a radio frequency-only storage trap to the orbitrap mass spectrometer (LTQ Orbitrap), and introduces a variable mass tolerance to improve certainty of peptide and small molecule identification.
Journal ArticleDOI
Higher-energy C-trap dissociation for peptide modification analysis.
TL;DR: Immonium ions generated via HCD pinpoint modifications such as phosphotyrosine with very high confidence are generated via higher-energy C-trap dissociation (HCD) and this work shows that an added octopole collision cell facilitates de novo sequencing.
Journal ArticleDOI
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.
Fumiyo Ikeda,Yonathan Lissanu Deribe,Sigrid S. Skånland,Benjamin Stieglitz,Caroline Grabbe,Caroline Grabbe,Mirita Franz-Wachtel,Sjoerd J L van Wijk,Panchali Goswami,Vanja Nagy,Janoš Terzić,Fuminori Tokunaga,Ariadne Androulidaki,Tomoko Nakagawa,Manolis Pasparakis,Kazuhiro Iwai,John P. Sundberg,Liliana Schaefer,Katrin Rittinger,Boris Macek,Ivan Dikic,Ivan Dikic +21 more
TL;DR: It is reported that SHARPIN functions as a novel component of the linear ubiquitin chain assembly complex (LUBAC) and that the absence of SHARPin causes dysregulation of NF-κB and apoptotic signalling pathways, explaining the severe phenotypes displayed by chronic proliferative dermatitis (cpdm) in SHARPIn-deficient mice.
Journal ArticleDOI
Metabolic priming by a secreted fungal effector
Armin Djamei,Kerstin Schipper,Kerstin Schipper,Kerstin Schipper,Franziska Rabe,Anupama Ghosh,Volker Vincon,Jörg Kahnt,Sonia Osorio,Takayuki Tohge,Alisdair R. Fernie,Ivo Feussner,Kirstin Feussner,Peter Meinicke,York-Dieter Stierhof,Heinz Schwarz,Boris Macek,Matthias Mann,Regine Kahmann +18 more
TL;DR: It is shown that the chorismate mutase Cmu1 secreted by U. maydis is a virulence factor, which is taken up by plant cells, can spread to neighbouring cells and changes the metabolic status of these cells through metabolic priming.