Ray Ranken

TL;DR: A new class of small molecules that bind the HCV RNA IRES IIA subdomain with sub-micromolar affinity is reported and activity in a cellular replicon assay at concentrations comparable to their KD for the RNA target is demonstrated.

TL;DR: These benzimidazoles are effective against both Gram-positive and Gram-negative bacteria of clinical importance, particularly enterococci, and represent a new class of potential antibacterial agents.

TL;DR: In this paper, a series of 2 O-substituted ether analogues of paromomycin were prepared based on new site-selective functionalizations, and X-ray cocrystal complexes of several such analogues revealed a new mode of binding in the A-site rRNA, whereby rings I and II adopted the familiar orientation and position previously observed with paromycin, but rings III and IV were oriented differently.

TL;DR: Several compounds showed low micromolar minimum inhibitory concentrations (MIC) against both Gram-positive and Gram-negative bacteria in a lethal murine model of bacterial septicemia.

TL;DR: The electrophilic fluorination of 4‐chloro‐5‐fluoro‐7‐(2,3,5,‐tri‐O‐benzoyl‐β‐d‐ribofuranosyl)pyrrolo[ 2,3‐d]pyrimidine was studied and increased activity of 7 over tubercidin was observed against L‐1210 cells and toxicity in fibroblast cells was reduced.