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David J. Ecker
Researcher at Isis Pharmaceuticals
Publications - 264
Citations - 16578
David J. Ecker is an academic researcher from Isis Pharmaceuticals. The author has contributed to research in topics: Oligonucleotide & RNA. The author has an hindex of 70, co-authored 263 publications receiving 16024 citations. Previous affiliations of David J. Ecker include Smith, Kline & French & University of South Florida.
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Journal ArticleDOI
A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein.
Vincent Chau,John W. Tobias,Andreas Bachmair,Andreas Bachmair,David Marriott,David J. Ecker,David K. Gonda,Alexander Varshavsky +7 more
TL;DR: The experiments with ubiquitin mutated at its Lys48 residue indicate that the multiubiquitin chain in a targeted protein is essential for the degradation of the protein.
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Analysis of Antibiotic Resistance Genes in Multidrug-Resistant Acinetobacter sp. Isolates from Military and Civilian Patients Treated at the Walter Reed Army Medical Center
Kristine M. Hujer,Andrea M. Hujer,Edward Hulten,Saralee Bajaksouzian,Jennifer Adams,Curtis J. Donskey,David J. Ecker,Christian Massire,Mark W. Eshoo,Rangarajan Sampath,Jodi M. Thomson,Philip N. Rather,David Craft,Joel Fishbain,Allesa J. Ewell,Michael R. Jacobs,David L. Paterson,Robert A. Bonomo,Robert A. Bonomo +18 more
TL;DR: A “snapshot” of the complex genetic background responsible for antimicrobial resistance in Acinetobacter spp.
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RNAMotif, an RNA secondary structure definition and search algorithm
Thomas J. Macke,David J. Ecker,Robin R. Gutell,Daniel Gautheret,David A. Case,Rangarajan Sampath +5 more
TL;DR: A new computational motif search algorithm that can describe an RNA structural element of any complexity and then search any nucleotide sequence database, including the complete prokaryotic and eukaryotic genomes, for these structural elements is described and its utility is demonstrated.
Journal ArticleDOI
Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant.
Daniel Finley,Seth Sadis,Brett P. Monia,Paul Boucher,David J. Ecker,Stanley T. Crooke,Vincent Chau +6 more
TL;DR: The recessive and dominant effects of a Lys-48-to-Arg mutant of ubiquitin (UbK48R) in Saccharomyces cerevisiae are characterized and expression of UbK 48R complements several phenotypes of polyubiquitin gene (UB14) deletion mutants.
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Ibis T5000: a universal biosensor approach for microbiology.
David J. Ecker,Rangarajan Sampath,Christian Massire,Lawrence B. Blyn,Thomas A. Hall,Mark W. Eshoo,Steven A. Hofstadler +6 more
TL;DR: The Ibis T5000 enables the identification and quantification of a broad set of pathogens, including all known bacteria, all major groups of pathogenic fungi and the major families of viruses that cause disease in humans and animals, along with the detection of virulence factors and antibiotic resistance markers.