R
Ray Ranken
Researcher at Isis Pharmaceuticals
Publications - 12
Citations - 400
Ray Ranken is an academic researcher from Isis Pharmaceuticals. The author has contributed to research in topics: Electrophilic fluorination & Pyrimidine. The author has an hindex of 8, co-authored 12 publications receiving 360 citations.
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Journal ArticleDOI
SAR by MS: Discovery of a New Class of RNA-Binding Small Molecules for the Hepatitis C Virus: Internal Ribosome Entry Site IIA Subdomain
Punit P. Seth,Alycia Miyaji,Elizabeth A. Jefferson,Kristin A. Sannes-Lowery,Stephen A. Osgood,Stephanie Propp,Ray Ranken,Christian Massire,Rangarajan Sampath,David J. Ecker,Eric E. Swayze,Richard H. Griffey +11 more
TL;DR: A new class of small molecules that bind the HCV RNA IRES IIA subdomain with sub-micromolar affinity is reported and activity in a cellular replicon assay at concentrations comparable to their KD for the RNA target is demonstrated.
Journal ArticleDOI
2-piperidin-4-yl-benzimidazoles with broad spectrum antibacterial activities.
Yun He,Baogen Wu,Jun Yang,Dale E. Robinson,Lisa M. Risen,Ray Ranken,Lawrence B. Blyn,Suzie Sheng,Eric E. Swayze +8 more
TL;DR: These benzimidazoles are effective against both Gram-positive and Gram-negative bacteria of clinical importance, particularly enterococci, and represent a new class of potential antibacterial agents.
Journal ArticleDOI
Structure-Based Design, Synthesis, and A-Site rRNA Cocrystal Complexes of Functionally Novel Aminoglycoside Antibiotics: C2'' Ether Analogues of Paromomycin
Stephen Hanessian,Janek Szychowski,Susanta Adhikari,Guillermo Vasquez,Pachamuthu Kandasamy,Eric E. Swayze,Michael T. Migawa,Ray Ranken,Boris François,Julia Wirmer-Bartoschek,Jiro Kondo,Eric Westhof +11 more
TL;DR: In this paper, a series of 2 O-substituted ether analogues of paromomycin were prepared based on new site-selective functionalizations, and X-ray cocrystal complexes of several such analogues revealed a new mode of binding in the A-site rRNA, whereby rings I and II adopted the familiar orientation and position previously observed with paromycin, but rings III and IV were oriented differently.
Journal ArticleDOI
Aryl urea analogs with broad-spectrum antibacterial activity.
Punit P. Seth,Ray Ranken,Dale E. Robinson,Stephen A. Osgood,Lisa M. Risen,Elizabeth L. Rodgers,Michael T. Migawa,Elizabeth A. Jefferson,Eric E. Swayze +8 more
TL;DR: Several compounds showed low micromolar minimum inhibitory concentrations (MIC) against both Gram-positive and Gram-negative bacteria in a lethal murine model of bacterial septicemia.
Journal ArticleDOI
Synthesis and biological activity of 5-fluorotubercidin.
TL;DR: The electrophilic fluorination of 4‐chloro‐5‐fluoro‐7‐(2,3,5,‐tri‐O‐benzoyl‐β‐d‐ribofuranosyl)pyrrolo[ 2,3‐d]pyrimidine was studied and increased activity of 7 over tubercidin was observed against L‐1210 cells and toxicity in fibroblast cells was reduced.