R
Raymond M. Shaheen
Researcher at University of Texas MD Anderson Cancer Center
Publications - 14
Citations - 2185
Raymond M. Shaheen is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor. The author has an hindex of 13, co-authored 14 publications receiving 2147 citations.
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Journal Article
Antiangiogenic Therapy Targeting the Tyrosine Kinase Receptor for Vascular Endothelial Growth Factor Receptor Inhibits the Growth of Colon Cancer Liver Metastasis and Induces Tumor and Endothelial Cell Apoptosis
Raymond M. Shaheen,Darren W. Davis,Wenbiao Liu,Brian K. Zebrowski,Michael R. Wilson,Corazon D. Bucana,David J. McConkey,Gerald McMahon,Lee M. Ellis +8 more
TL;DR: VEGF receptor inhibitors increased endothelial cell apoptosis, suggesting that VEGF may serve as an endothelial survival factor.
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Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors
Raymond M. Shaheen,Syed A. Ahmad,Wenbiao Liu,Niels Reinmuth,Young Do Jung,William W. Tseng,Kenneth E. Drazan,Corazon D. Bucana,Daniel J. Hicklin,Lee M. Ellis +9 more
TL;DR: It is suggested that DC101 inhibits angiogenesis, endothelial cell survival, and VEGF-mediated ascites formation in a murine model of colon cancer carcinomatosis, and combination anti-VEGF and anti-EGFR therapy may represent a novel therapeutic strategy for the management of colon peritoneal carcinom atosis.
Journal ArticleDOI
Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival.
Niels Reinmuth,Wenbiao Liu,Young Do Jung,Syed A. Ahmad,Raymond M. Shaheen,Fan Fan,Corazon D. Bucana,Gerald McMahon,Gary E. Gallick,Lee M. Ellis +9 more
TL;DR: It is hypothesized that PDGF (platelet‐derived growth factor)‐BB, a cytokine released from tumor and ECs, mediates pericyte function by inducing VEGF, which in turn may affect EC survival.
Journal Article
The Effects of Angiopoietin-1 and -2 on Tumor Growth and Angiogenesis in Human Colon Cancer
Syed A. Ahmad,Wenbiao Liu,Young Do Jung,Fan Fan,Michael R. Wilson,Niels Reinmuth,Raymond M. Shaheen,Corazon D. Bucana,Lee M. Ellis +8 more
TL;DR: The data suggest that imbalances between Ang-1 and -2 that result in a net gain of Ang-2 activity lead to enhanced tumor angiogenesis and growth.
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Vascular endothelial growth factor in human colon cancer: biology and therapeutic implications.
TL;DR: Results showed that targeting the VEGF receptor/ligand system is a rational approach to inhibiting tumor growth and prolonging survival.