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Rebecca M. Brotman
Researcher at University of Maryland, Baltimore
Publications - 97
Citations - 9319
Rebecca M. Brotman is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Bacterial vaginosis & Medicine. The author has an hindex of 31, co-authored 86 publications receiving 7091 citations. Previous affiliations of Rebecca M. Brotman include National Institutes of Health & The Research Institute at Nationwide Children's Hospital.
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Journal ArticleDOI
Vaginal microbiome of reproductive-age women
Jacques Ravel,Pawel Gajer,Zaid Abdo,G. Maria Schneider,Sara S. K. Koenig,Stacey L. McCulle,Shara Karlebach,Reshma Gorle,Jennifer Russell,Carol O. Tacket,Rebecca M. Brotman,Catherine C. Davis,Kevin A. Ault,Ligia Peralta,Larry J. Forney +14 more
TL;DR: The inherent differences within and between women in different ethnic groups strongly argues for a more refined definition of the kinds of bacterial communities normally found in healthy women and the need to appreciate differences between individuals so they can be taken into account in risk assessment and disease diagnosis.
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An improved dual-indexing approach for multiplexed 16S rRNA gene sequencing on the Illumina MiSeq platform
Douglas Fadrosh,Bing Ma,Pawel Gajer,Naomi Sengamalay,Sandra Ott,Rebecca M. Brotman,Jacques Ravel +6 more
TL;DR: An improved dual-indexing amplification and sequencing approach to assess the composition of microbial communities from clinical samples using the V3-V4 region of the 16S rRNA gene on the Illumina MiSeq platform by introducing a 0 to 7 bp “heterogeneity spacer” to the index sequence that allows an equal proportion of samples to be sequenced out of phase.
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Temporal Dynamics of the Human Vaginal Microbiota
Pawel Gajer,Rebecca M. Brotman,Guoyun Bai,Joyce M. Sakamoto,Ursel M. E. Schütte,Xue Zhong,Sara S. K. Koenig,Li Fu,Zhanshan Sam Ma,Xia Zhou,Zaid Abdo,Larry J. Forney,Jacques Ravel +12 more
TL;DR: The temporal dynamics of the composition of vaginal bacterial communities in 32 reproductive-age women over a 16-week period revealed the dynamics of five major classes of bacterial communities and showed that some communities change markedly over short time periods, whereas others are relatively stable.
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Bacterial vaginosis assessed by gram stain and diminished colonization resistance to incident gonococcal, chlamydial, and trichomonal genital infection.
Rebecca M. Brotman,Mark A. Klebanoff,Tonja R. Nansel,Kai F. Yu,William W. Andrews,Jun Zhang,Jane R. Schwebke +6 more
TL;DR: BV microbiota as gauged by Gram stain is associated with a significantly elevated risk for acquisition of trichomonal, gonococcal, and/or chlamydial genital infection.
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Association between the vaginal microbiota, menopause status, and signs of vulvovaginal atrophy
Rebecca M. Brotman,Michelle Shardell,Pawel Gajer,Douglas Fadrosh,Kathryn Chang,Michelle I. Silver,Raphael P. Viscidi,Anne E. Burke,Jacques Ravel,Patti E. Gravitt +9 more
TL;DR: This study provides an impetus for future longitudinal studies designed to manage, modulate, and restore vaginal microbiota homeostasis, which would provide stronger evidence for a causal relationship with VVA and ultimately improve the treatment and prevention of atrophic vaginitis in menopause.