R
Reiling Liao
Researcher at Seattle Biomed
Publications - 8
Citations - 2770
Reiling Liao is an academic researcher from Seattle Biomed. The author has contributed to research in topics: Mycobacterium tuberculosis & Gene. The author has an hindex of 8, co-authored 8 publications receiving 2588 citations. Previous affiliations of Reiling Liao include University of Washington.
Papers
More filters
Journal ArticleDOI
Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding α-crystallin
David R. Sherman,Martin I. Voskuil,Dirk Schnappinger,Reiling Liao,Maria I. Harrell,Gary K. Schoolnik +5 more
TL;DR: The results suggest a possible role for Rv3132c/3133c/Rv3134c in mycobacterial latency, and an apparent operon that includes the putative two-component response regulator pair R v3133/3132/3134/3 134c is suggested.
Journal ArticleDOI
Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis.
Heui-Dong Park,Kristi M. Guinn,Maria I. Harrell,Reiling Liao,Martin I. Voskuil,Martin Tompa,Gary K. Schoolnik,David R. Sherman +7 more
TL;DR: Results demonstrate that Rv3133c/DosR is a transcription factor of the two‐component response regulator class, and that it is the primary mediator of a hypoxic signal within M. tuberculosis.
Journal ArticleDOI
Deletion of RD1 from Mycobacterium tuberculosis Mimics Bacille Calmette-Guérin Attenuation
Kaeryn N. Lewis,Reiling Liao,Kristi M. Guinn,Mark J. Hickey,Sherilyn Smith,Marcel A. Behr,David R. Sherman +6 more
TL;DR: It was concluded that genes within or controlled by RD1 are essential for MTB virulence and that loss of RD1 was important in BCG attenuation.
Journal ArticleDOI
The Enduring Hypoxic Response of Mycobacterium tuberculosis
Tige R. Rustad,Tige R. Rustad,Maria I. Harrell,Maria I. Harrell,Reiling Liao,David R. Sherman,David R. Sherman +6 more
TL;DR: It is shown here that a dosR deletion mutant enters bacteriostasis in response to in vitro hypoxia with only a relatively mild decrease in viability, which suggested that additional genes may be essential for entry into and maintenance of bacter iostasis.
Journal ArticleDOI
Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis
Thomas R. Ioerger,Theresa O’Malley,Reiling Liao,Kristine M. Guinn,Mark J. Hickey,Nilofar Mohaideen,Kenan C. Murphy,Helena I. Boshoff,Valerie Mizrahi,Eric J. Rubin,Christopher M. Sassetti,Christopher M. Sassetti,Clifton E. Barry,David R. Sherman,Tanya Parish,James C. Sacchettini +15 more
TL;DR: This work has developed a scalable platform for target identification in M. tuberculosis that is based on whole-cell screening, coupled with whole-genome sequencing of resistant mutants and recombineering to confirm, and identified resistance-linked genes for eight compounds with anti-tubercular activity.