R
Reinhold J. Medina
Researcher at Queen's University Belfast
Publications - 67
Citations - 4206
Reinhold J. Medina is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Progenitor cell & Angiogenesis. The author has an hindex of 27, co-authored 60 publications receiving 3401 citations. Previous affiliations of Reinhold J. Medina include Queen's University & Okayama University.
Papers
More filters
Journal ArticleDOI
The progress in understanding and treatment of diabetic retinopathy
Alan W. Stitt,Tim M. Curtis,Mei Chen,Reinhold J. Medina,Gareth J. McKay,Alicia J. Jenkins,Tom A. Gardiner,Timothy J. Lyons,Hans-Peter Hammes,Rafael Simó,Noemi Lois +10 more
TL;DR: It is emphasised that although there have been significant advances, there is still a pressing need for a better understanding basic mechanisms enable development of reliable and robust means to identify patients at highest risk, and to intervene effectively before vision loss occurs.
Journal ArticleDOI
Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types
Jasenka Guduric-Fuchs,Anna O’Connor,Bailey Camp,Christina L. O'Neill,Reinhold J. Medina,David Simpson +5 more
TL;DR: Overexpressed miR-146a was highly enriched both in transfected cells and their EVs, and the cellular:EV ratios of endogenous miRNAs were not grossly altered, suggesting a common mechanism for selective miRNA export may exist.
Journal ArticleDOI
Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities
Reinhold J. Medina,Christina L. O'Neill,Mark Sweeney,Jasenka Guduric-Fuchs,Tom A. Gardiner,David Simpson,Alan W. Stitt +6 more
TL;DR: Evidence is provided that eEPCs are haematopoietic cells with a molecular phenotype linked to monocytes; whereas OECs exhibit commitment to the endothelial lineage and should be used with caution because of their monocytic nature.
Journal ArticleDOI
Endothelial Progenitors: A Consensus Statement on Nomenclature.
Reinhold J. Medina,Chad L. Barber,Florence Sabatier,Françoise Dignat-George,Juan M. Melero-Martin,Juan M. Melero-Martin,Kiarash Khosrotehrani,Osamu Ohneda,Anna M. Randi,Jerry Kok Yen Chan,Teruhide Yamaguchi,Victor W.M. van Hinsbergh,Mervin C. Yoder,Alan W. Stitt +13 more
TL;DR: This review seeks to discourage the indiscriminate use of “EPCs,” and instead proposes precise terminology based on defining cellular phenotype and function, which should become more precise in the light of strong scientific evidence.
Journal ArticleDOI
Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony–forming cells
Nutan Prasain,Man Ryul Lee,Sasidhar Vemula,Jonathan Luke Meador,Momoko Yoshimoto,Michael J. Ferkowicz,Alexa Fett,Manav Gupta,Brian M. Rapp,Mohammad Reza Saadatzadeh,Michael Ginsberg,Olivier Elemento,Younghee Lee,Sherry L. Voytik-Harbin,Hyung-Min Chung,Ki Sung Hong,Emma Reid,Christina L. O'Neill,Reinhold J. Medina,Alan W. Stitt,Michael P. Murphy,Shahin Rafii,Hal E. Broxmeyer,Mervin C. Yoder +23 more
TL;DR: A protocol to convert human induced pluripotent stem cells or embryonic stem cells into cells similar to CB-ECFCs at an efficiency of >108 ECFCs produced from each starting pluripotencephalic stem cell is described.