R
Reinis R. Ruza
Researcher at University of Oxford
Publications - 20
Citations - 1282
Reinis R. Ruza is an academic researcher from University of Oxford. The author has contributed to research in topics: Epitope & Notum. The author has an hindex of 9, co-authored 18 publications receiving 819 citations. Previous affiliations of Reinis R. Ruza include Pasteur Institute.
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Journal ArticleDOI
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2.
J. Huo,J. Huo,A. Le Bas,A. Le Bas,Reinis R. Ruza,Duyvesteyn Hme.,H. Mikolajek,Tomas Malinauskas,Tiong Kit Tan,Pramila Rijal,Pramila Rijal,Maud Dumoux,Philip N. Ward,Philip N. Ward,Jingshan Ren,D. Zhou,Peter J. Harrison,Peter J. Harrison,Miriam Weckener,Daniel K. Clare,V K Vogirala,Julika Radecke,Lucile Moynié,Yuguang Zhao,Javier Gilbert-Jaramillo,Michael L. Knight,Julia A. Tree,Karen R. Buttigieg,Naomi Coombes,Michael J. Elmore,Miles W. Carroll,Loic Carrique,Shah Pnm.,William James,Alain Townsend,Alain Townsend,David I. Stuart,Raymond J. Owens,Raymond J. Owens,James H. Naismith,James H. Naismith +40 more
TL;DR: Two nanobodies that bind SARS-CoV-2 spike RBD are shown to block interaction with receptor ACE2 and thus neutralize the virus, and have an additive effect with antibody CR3022.
Journal ArticleDOI
Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike.
Jiandong Huo,Jiandong Huo,Yuguang Zhao,Jingshan Ren,D. Zhou,Helen M. E. Duyvesteyn,Helen M. Ginn,Loic Carrique,Tomas Malinauskas,Reinis R. Ruza,Pranav N.M. Shah,Tiong Kit Tan,Pramila Rijal,Naomi Coombes,Kevin R. Bewley,Julia A. Tree,Julika Radecke,Neil G. Paterson,P Supasa,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton,Miles W. Carroll,Miles W. Carroll,Alain Townsend,Elizabeth E. Fry,Raymond J. Owens,Raymond J. Owens,David I. Stuart +28 more
TL;DR: It is found that the monoclonal antibody CR3022 binds the RBD tightly, neutralising SARS-CoV-2 and the crystal structure at 2.4 Å of the Fab/RBD complex is reported, suggesting that CR30 22 binding facilitates conversion to the fusion-incompetent post-fusion state.
Journal ArticleDOI
Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient.
D. Zhou,Duyvesteyn Hme.,Chen C-P.,Huang C-G.,Huang C-G.,Chen T-H.,Shih S-R.,Shih S-R.,Lin Y-C.,Cheng C-Y.,Cheng S-H.,Huang Y-C.,Lin T-Y.,Che Ma,J. Huo,J. Huo,Loic Carrique,Tomas Malinauskas,Reinis R. Ruza,Shah Pnm.,Tiong Kit Tan,Pramila Rijal,Pramila Rijal,R F Donat,Kerry J Godwin,Karen R. Buttigieg,Julia A. Tree,Julika Radecke,Neil G. Paterson,P Supasa,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton,Miles W. Carroll,Miles W. Carroll,Javier Gilbert-Jaramillo,Michael L. Knight,William James,Raymond J. Owens,Raymond J. Owens,James H. Naismith,James H. Naismith,Alain Townsend,Alain Townsend,Elizabeth E. Fry,Yuguang Zhao,Jingshan Ren,David I. Stuart,Huang K-Ya.,Huang K-Ya. +49 more
TL;DR: EY6A, a neutralizing antibody isolated from a patient convalescing from COVID-19, binds the receptor binding domain of the SARS-CoV-2 spike glycoprotein with high affinity, at a location away from the binding site for the ACE2 receptor, similar to the one recognized by CR3022.
Journal ArticleDOI
Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike
Jiandong Huo,Yuguang Zhao,Jingshan Ren,D. Zhou,Helen M. E. Duyvesteyn,Helen M. Ginn,Loic Carrique,Tomas Malinauskas,Reinis R. Ruza,Pranav N.M. Shah,Tiong Kit Tan,Pramila Rijal,Naomi Coombes,Kevin R. Bewley,Julia A. Tree,Julika Radecke,Neil G. Paterson,P Supasa,Juthathip Mongkolsapaya,Gavin R. Screaton,Miles W. Carroll,Alain Townsend,Elizabeth E. Fry,Raymond J. Owens,David I. Stuart +24 more
TL;DR: It is found that monoclonal antibody CR3022 binds the RBD tightly, neutralising SARS-CoV-2 and the crystal structure at 2.4 A of the Fab/RBD complex is reported, suggesting the highly conserved, structure-stabilising,CR3022 epitope is inaccessible in the prefusion Spike, suggesting that CR30 22 binding would facilitate conversion to the fusion-incompetent post-fusion state.
Journal ArticleDOI
Erratum: Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike (Cell Host & Microbe (2020) 28(3) (445–454.e6), (S1931312820303516), (10.1016/j.chom.2020.06.010))
J. Huo,Yuguang Zhao,Jingshan Ren,D. Zhou,Duyvesteyn Hme.,Helen M. Ginn,Loic Carrique,Tomas Malinauskas,Reinis R. Ruza,Shah Pnm.,Tiong Kit Tan,Pramila Rijal,Naomi Coombes,Kevin R. Bewley,Julia A. Tree,Julika Radecke,Neil G. Paterson,P Supasa,Juthathip Mongkolsapaya,Gavin R. Screaton,Miles W. Carroll,Alain Townsend,Elizabeth E. Fry,Raymond J. Owens,David I. Stuart +24 more
TL;DR: In the version of this article published online June 19, 2020, there was a spelling error in author Piyada Supasa's name, and a spike ectodomain was incorrectly stated to contain an His-6 tag instead of an Her-8 tag as discussed by the authors.