P
Pranav N.M. Shah
Researcher at University of Oxford
Publications - 18
Citations - 614
Pranav N.M. Shah is an academic researcher from University of Oxford. The author has contributed to research in topics: Biology & Epitope. The author has an hindex of 7, co-authored 14 publications receiving 420 citations. Previous affiliations of Pranav N.M. Shah include Heidelberg University & University Hospital Heidelberg.
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Journal ArticleDOI
Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike.
Jiandong Huo,Jiandong Huo,Yuguang Zhao,Jingshan Ren,D. Zhou,Helen M. E. Duyvesteyn,Helen M. Ginn,Loic Carrique,Tomas Malinauskas,Reinis R. Ruza,Pranav N.M. Shah,Tiong Kit Tan,Pramila Rijal,Naomi Coombes,Kevin R. Bewley,Julia A. Tree,Julika Radecke,Neil G. Paterson,P Supasa,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton,Miles W. Carroll,Miles W. Carroll,Alain Townsend,Elizabeth E. Fry,Raymond J. Owens,Raymond J. Owens,David I. Stuart +28 more
TL;DR: It is found that the monoclonal antibody CR3022 binds the RBD tightly, neutralising SARS-CoV-2 and the crystal structure at 2.4 Å of the Fab/RBD complex is reported, suggesting that CR30 22 binding facilitates conversion to the fusion-incompetent post-fusion state.
Journal ArticleDOI
Understanding the Wolbachia-mediated inhibition of arboviruses in mosquitoes: progress and challenges.
TL;DR: This review will summarize recent work and discuss determinants of antiviral effectiveness that may differ between individual Wolbachia/vector/arbovirus interactions, and the application of this approach to field settings and the associated risks.
Journal ArticleDOI
Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike
Jiandong Huo,Yuguang Zhao,Jingshan Ren,D. Zhou,Helen M. E. Duyvesteyn,Helen M. Ginn,Loic Carrique,Tomas Malinauskas,Reinis R. Ruza,Pranav N.M. Shah,Tiong Kit Tan,Pramila Rijal,Naomi Coombes,Kevin R. Bewley,Julia A. Tree,Julika Radecke,Neil G. Paterson,P Supasa,Juthathip Mongkolsapaya,Gavin R. Screaton,Miles W. Carroll,Alain Townsend,Elizabeth E. Fry,Raymond J. Owens,David I. Stuart +24 more
TL;DR: It is found that monoclonal antibody CR3022 binds the RBD tightly, neutralising SARS-CoV-2 and the crystal structure at 2.4 A of the Fab/RBD complex is reported, suggesting the highly conserved, structure-stabilising,CR3022 epitope is inaccessible in the prefusion Spike, suggesting that CR30 22 binding would facilitate conversion to the fusion-incompetent post-fusion state.
Journal ArticleDOI
Bin1 directly remodels actin dynamics through its BAR domain
Nina M. Dräger,Eliana Nachman,Eliana Nachman,Moritz Winterhoff,Stefan Brühmann,Pranav N.M. Shah,Taxiarchis Katsinelos,Steeve Boulant,Steeve Boulant,Aurelio A. Teleman,Jan Faix,Thomas R. Jahn +11 more
TL;DR: The ability of Bin1 to modify actin dynamics and provide a possible mechanistic connection between Bin1 and tau‐induced pathobiological changes of the actin cytoskeleton are revealed.
Posted ContentDOI
Neutralization of SARS-CoV-2 by destruction of the prefusion Spike
Jiandong Huo,Jiandong Huo,Yuguang Zhao,Jingshan Ren,D. Zhou,Helen M. E. Duyvesteyn,Helen M. Ginn,Loic Carrique,Tomas Malinauskas,Reinis R. Ruza,Pranav N.M. Shah,Tiong Kit Tan,Pramila Rijal,Naomi Coombes,Kevin R. Bewley,Julika Radecke,Neil G. Paterson,P Supasa,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton,Miles W. Carroll,Miles W. Carroll,Alain Townsend,Elizabeth E. Fry,Raymond J. Owens,Raymond J. Owens,David I. Stuart +27 more
TL;DR: It is found that monoclonal antibody CR3022 binds the RBD tightly, neutralising SARS-CoV-2 and the crystal structure at 2.4 Å of the Fab/RBD complex is reported, suggesting this epitope may be useful therapeutically, possibly in synergy with an antibody blocking receptor attachment.