H
Helen M. Ginn
Researcher at University of Oxford
Publications - 52
Citations - 5506
Helen M. Ginn is an academic researcher from University of Oxford. The author has contributed to research in topics: Neutralization & Antibody. The author has an hindex of 22, co-authored 45 publications receiving 2153 citations. Previous affiliations of Helen M. Ginn include Public Health England & Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera.
D. Zhou,Wanwisa Dejnirattisai,P Supasa,Chang Liu,Alexander J. Mentzer,Helen M. Ginn,Yuguang Zhao,Duyvesteyn Hme.,Aekkachai Tuekprakhon,R Nutalai,Beibei Wang,Guido C. Paesen,Cesar Lopez-Camacho,J Slon-Campos,Bassam Hallis,Naomi Coombes,Kevin R. Bewley,Sue Charlton,Thomas S. Walter,Donal T. Skelly,Sheila F Lumley,Christina Dold,R Levin,Tao Dong,Andrew J. Pollard,Julian C. Knight,Derrick W. Crook,Teresa Lambe,Elizabeth A. Clutterbuck,S Bibi,Amy Flaxman,M Bittaye,Sandra Belij-Rammerstorfer,Sarah C. Gilbert,William James,Miles W. Carroll,Paul Klenerman,Eleanor Barnes,Susanna Dunachie,Elizabeth E. Fry,Juthathip Mongkolsapaya,Jingshan Ren,David I. Stuart,Gavin R. Screaton +43 more
TL;DR: In this paper, a structure-function analysis of B.1.351 was performed using a large cohort of convalescent and vaccinee serum samples, and it was shown that the receptor-binding domain mutations provide tighter ACE2 binding and widespread escape from monoclonal antibody neutralization largely driven by E484K, although K417N and N501Y act together against some important antibody classes.
Journal ArticleDOI
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses
Wanwisa Dejnirattisai,Jiandong Huo,D. Zhou,Jiří Zahradník,P Supasa,Changxiao Liu,Helen M. E. Duyvesteyn,Helen M. Ginn,Alexander J. Mentzer,Aekkachai Tuekprakhon,Rungtiwa Nutalai,Beibei Wang,Aiste Dijokaite,Suman Khan,Ori Avinoam,M.W. Bahar,Donal T. Skelly,S Adele,Síle A. Johnson,Thomas G Ritter,Chris Jb Mason,Christina Dold,Daniel Pan,Sara Assadi,A. Bellass,Nikki Omo-Dare,David Koeckerling,Amy Flaxman,D Jenkin,Parvinder K. Aley,Merryn Voysey,Sue Ann Costa Clemens,Felipe Gomes Naveca,Valdinete Alves do Nascimento,Fernanda Nascimento,Cristiano Fernandes da Costa,Paola Cristina Resende,Alex Pauvolid-Corrêa,Marilda M. Siqueira,Vicky L. Baillie,Natali Serafin,Gaurav Kwatra,Kelly Da Silva,Shabir A. Madhi,Marta C. Nunes,Tariq Mehmood Malik,Peter J. M. Openshaw,J Kenneth Baillie,Malcolm G Semple,Alain Townsend,Kuan-Ying A. Huang,Tiong Kit Tan,Miles W. Carroll,Paul Klenerman,Eleanor Barnes,Susanna Dunachie,Bede Constantinides,Hermione J. Webster,Derrick W. Crook,Andrew J. Pollard,Teresa Lambe,Neil G. Paterson,Mark Williams,Elizabeth E. Fry,Juthathip Mongkolsapaya,Jingshan Ren,Gideon Schreiber,David Stuart,Gavin R. Screaton +68 more
TL;DR: In this article , a new SARS-CoV-2 viral isolate Omicron-B.1.529 was announced, containing far more mutations in Spike (S) than previously reported variants, leading to a large number of mutations in the ACE2 binding site and rebalances receptor affinity to that of earlier pandemic viruses.
Journal ArticleDOI
Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum.
Chang Liu,Helen M. Ginn,Wanwisa Dejnirattisai,P Supasa,Beibei Wang,Aekkachai Tuekprakhon,R Nutalai,D. Zhou,Alexander J. Mentzer,Yuguang Zhao,Duyvesteyn Hme.,Cesar Lopez-Camacho,J Slon-Campos,Thomas S. Walter,Donal T. Skelly,S A Johnson,T G Ritter,C Mason,S A Costa Clemens,F. Gomes Naveca,Valdinete Alves do Nascimento,Fabrícia F. Nascimento,C Fernandes da Costa,Paola Cristina Resende,Alex Pauvolid-Corrêa,Marilda M. Siqueira,Christina Dold,Nigel J. Temperton,Tao Dong,Andrew J. Pollard,James C. Knight,D W Crook,Teresa Lambe,Elizabeth A. Clutterbuck,S Bibi,Amy Flaxman,M Bittaye,Sandra Belij-Rammerstorfer,Sarah C. Gilbert,T Malik,Miles W. Carroll,Paul Klenerman,Eleanor Barnes,Susanna Dunachie,Vicky L. Baillie,Vicky L. Baillie,N Serafin,N Serafin,Z Ditse,Z Ditse,K Da Silva,K Da Silva,Neil G. Paterson,Mark A. Williams,David Hall,Shabir A. Madhi,Shabir A. Madhi,M C Nunes,M C Nunes,P Goulder,Elizabeth E. Fry,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Jingshan Ren,David I. Stuart,Gavin R. Screaton +65 more
TL;DR: In this paper, the ability of monoclonal antibodies and convalescent and vaccine sera to neutralize B.617.1 and B.1.2 has been studied.
Journal ArticleDOI
Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum
Aekkachai Tuekprakhon,Jiandong Huo,Rungtiwa Nutalai,Aiste Dijokaite-Guraliuc,D. Zhou,Helen M. Ginn,Muneeswaran Selvaraj,Changxiao Liu,Alexander J. Mentzer,P Supasa,Helen M. E. Duyvesteyn,Raksha Das,Donal T. Skelly,Thomas G Ritter,S Bibi,S Adele,Síle A. Johnson,Bede Constantinides,Hermione J. Webster,Nigel J. Temperton,Paul Klenerman,Eleanor Barnes,Susanna Dunachie,Derrick W. Crook,Andrew J. Pollard,Teresa Lambe,Philip J. R. Goulder,Neil G. Paterson,Mark Williams,Elizabeth E. Fry,Juthathip Mongkolsapaya,Jingshan Ren,David I. Stuart,Gavin R. Screaton,Christopher P. Conlon,Alexandra Deeks,John Frater,Lisa Frending,Siobhan Gardiner,Anni Jämsén,Katie Jeffery,Tom Malone,Eloise Phillips,Lucy Rothwell,L Stafford +44 more
TL;DR: In this article , the neutralization of BA.4 and BA.5 has been studied using a range of vaccine and naturally immune serum and panels of monoclonal antibodies.
Journal ArticleDOI
Antibody evasion by the P.1 strain of SARS-CoV-2.
Wanwisa Dejnirattisai,D. Zhou,P Supasa,Chang Liu,Alexander J. Mentzer,Helen M. Ginn,Yuguang Zhao,Duyvesteyn Hme.,Aekkachai Tuekprakhon,R Nutalai,Beibei Wang,Cesar Lopez-Camacho,J Slon-Campos,Thomas S. Walter,Donal T. Skelly,S A Costa Clemens,Felipe Gomes Naveca,Valdinete Alves do Nascimento,Fabrícia F. Nascimento,C Fernandes da Costa,Paola Cristina Resende,Alex Pauvolid-Corrêa,Marilda M. Siqueira,Christina Dold,R Levin,Tao Dong,Andrew J. Pollard,Julian C. Knight,D W Crook,Teresa Lambe,Elizabeth A. Clutterbuck,S Bibi,Amy Flaxman,M Bittaye,Sandra Belij-Rammerstorfer,Sarah C. Gilbert,Miles W. Carroll,Paul Klenerman,E Barnes,Susanna Dunachie,Neil G. Paterson,Mark A. Williams,David R. Hall,Hulswit Rjg.,Thomas A. Bowden,Elizabeth E. Fry,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Jingshan Ren,David I. Stuart,Gavin R. Screaton +50 more
TL;DR: In this paper, structural analysis of the ACE2 binding sites of the SARS-CoV-2 pandemic strain has been carried out and the authors show that the 222 light chain is able to largely restore neutralization potency to a major class of public antibodies.