Rekha G. Panchal

TL;DR: It is found that the mutation in GABRG2 (encoding the γ2-subunit) abolished in vitro sensitivity to diazepam, raising the possibility that endozepines do in fact exist and have a physiological role in preventing seizures.

TL;DR: A structure-function analysis of truncated and single-residue-mutated P2X7 receptors revealed that mutations of single residues within this region could also abolish receptor function and cell surface expression, suggesting that this region may participate in regulating the surface expression of the pore-forming P2x7R.

TL;DR: It is unlikely that large scale changes in P2X7 receptor density precede pore formation, and simultaneous monitoring of EGFP and ethidium ion fluorescence revealed that changes in receptor distribution do not precedepore formation.

TL;DR: Results suggest that not all “antiarrhythmic” fatty acids target the same channel, and suggest that hminK confers fatty acid sensitivity to IKs.

TL;DR: In this article, the authors describe enhancement of the deficient Ca(2+) handling properties evident in myocytes from hypertrophied hearts following adenoviral-mediated transfer of the human Serca2a gene to these myocytes.