G
Grant R. Sutherland
Researcher at Boston Children's Hospital
Publications - 298
Citations - 27057
Grant R. Sutherland is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Gene & Gene mapping. The author has an hindex of 77, co-authored 298 publications receiving 26357 citations. Previous affiliations of Grant R. Sutherland include Royal Children's Hospital & University of Calgary.
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Journal ArticleDOI
Identification and characterization of a new member of the TNF family that induces apoptosis
Steven R. Wiley,Ken Schooley,Pamela J. Smolak,Wenie S. Din,Chang-Pin Huang,Jillian Nicholl,Grant R. Sutherland,Terri Davis Smith,Charles Rauch,Craig A. Smith,Raymond G. Goodwin +10 more
TL;DR: A novel tumor necrosis factor (TNF) family member has been cloned and characterized, and the TRAIL gene is located on chromosome 3 at position 3q26, which is not close to any other known TNF ligand family members.
Journal ArticleDOI
A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy.
Ortrud K. Steinlein,John C. Mulley,Peter Propping,Robyn H. Wallace,Robyn H. Wallace,H.A. Phillips,Grant R. Sutherland,Grant R. Sutherland,Ingrid E. Scheffer,Ingrid E. Scheffer,Samuel F. Berkovic,Samuel F. Berkovic +11 more
TL;DR: A missense mutation that replaces serine with phenylalanine at codon 248, a strongly conserved amino acid residue in the second transmembrane domain is found in all 21 available affected family members and in four obligate carriers, but not in 333 healthy control subjects.
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Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B.
Robyn H. Wallace,Dao W. Wang,Rita Singh,Rita Singh,Ingrid E. Scheffer,Ingrid E. Scheffer,Ingrid E. Scheffer,Alfred L. George,H.A. Phillips,Kathrin Saar,André Reis,Eric W. Johnson,Grant R. Sutherland,Grant R. Sutherland,Samuel F. Berkovic,Samuel F. Berkovic,John C. Mulley,John C. Mulley +17 more
TL;DR: It is shown that co-expression of the mutant ß1 subunit with a brain Na+-channel ß subunit in Xenopus laevis oocytes demonstrates that the mutation interferes with the ability of the subunit to modulate channel-gating kinetics consistent with a loss-of-function allele, developing the theme that idiopathic epilepsies are a family of channelopathies.
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Mutant GABA A receptor γ2-subunit in childhood absence epilepsy and febrile seizures
Robyn H. Wallace,Carla Marini,Steven Petrou,Louise A. Harkin,Louise A. Harkin,David N. Bowser,Rekha G. Panchal,David A. Williams,Grant R. Sutherland,Grant R. Sutherland,John C. Mulley,John C. Mulley,Ingrid E. Scheffer,Ingrid E. Scheffer,Samuel F. Berkovic,Samuel F. Berkovic +15 more
TL;DR: It is found that the mutation in GABRG2 (encoding the γ2-subunit) abolished in vitro sensitivity to diazepam, raising the possibility that endozepines do in fact exist and have a physiological role in preventing seizures.
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DNAM-1, A Novel Adhesion Molecule Involved in the Cytolytic Function of T Lymphocytes
Akira Shibuya,David Campbell,Charles Hannum,Hans Yssel,Karin Franz-Bacon,Terrill K. McClanahan,Toshio Kitamura,Jillian Nicholl,Grant R. Sutherland,Lewis L. Lanier,Joseph H. Phillips +10 more
TL;DR: A novel accessory molecule, DNAX accessory molecule-1 (DNAM-1), that is constitutively expressed on the majority of peripheral blood T lymphocytes that participates in primary adhesion during cytotoxic T lymphocyte (CTL)-mediated cytotoxicity.