R
Renato Leonardo de Freitas
Researcher at University of São Paulo
Publications - 34
Citations - 751
Renato Leonardo de Freitas is an academic researcher from University of São Paulo. The author has contributed to research in topics: Neuropathic pain & Allodynia. The author has an hindex of 14, co-authored 31 publications receiving 584 citations. Previous affiliations of Renato Leonardo de Freitas include Universidade Federal de Alfenas.
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Neuroanatomical approaches of the tectum-reticular pathways and immunohistochemical evidence for serotonin-positive perikarya on neuronal substrates of the superior colliculus and periaqueductal gray matter involved in the elaboration of the defensive behavior and fear-induced analgesia.
Norberto Cysne Coimbra,R. de Oliveira,Renato Leonardo de Freitas,S.J. Ribeiro,Karina Genaro Borelli,Karina Genaro Borelli,Rodolfo C. Pacagnella,J.E. Moreira,L. da Silva,L. da Silva,L.L. Melo,L.L. Melo,L.O. Lunardi,Marcus Lira Brandão +13 more
TL;DR: These findings support the contention that serotonin and GABAergic neurons may act in concert in the modulation of defense reaction in the midbrain tectum, and indicate a direct neural pathway connecting the dorsal midbrain and monoaminergic nuclei of the descending pain inhibitory system.
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Effect of the blockade of μ1-opioid and 5HT2A-serotonergic/α1-noradrenergic receptors on sweet-substance-induced analgesia
E. C. C. Rebouças,E. C. C. Rebouças,E.N. Segato,Renato Kishi,Renato Leonardo de Freitas,M. Savoldi,Silvio Morato,Norberto Cysne Coimbra +7 more
TL;DR: Naltrexone and methysergide at two major doses decreased sweet-substance-induced analgesia after chronic intake of a sweet substance, and were corroborated by peripheral administration of naloxonazine and ketanserin.
Journal ArticleDOI
Intrinsic neural circuits between dorsal midbrain neurons that control fear-induced responses and seizure activity and nuclei of the pain inhibitory system elaborating postictal antinociceptive processes: a functional neuroanatomical and neuropharmacological study.
Renato Leonardo de Freitas,Célio Marcos dos Reis Ferreira,Sandro José Ribeiro,Andressa Daiane Carvalho,D.H. Elias-Filho,Norberto Garcia-Cairasco,Norberto Cysne Coimbra +6 more
TL;DR: The functional neuroanatomical study of the neural link between the mesencephalic tectum and nuclei of the central pain inhibitory system showed evidence for the interconnection between superior colliculus, both dorsal and ventral periaqueductal gray matter (PAG), and inferiorColliculus.
Journal ArticleDOI
GABA(A) receptor blockade in dorsomedial and ventromedial nuclei of the hypothalamus evokes panic-like elaborated defensive behaviour followed by innate fear-induced antinociception
Renato Leonardo de Freitas,A. Uribe-Mariño,M.A. Castiblanco-Urbina,D.H. Elias-Filho,Norberto Cysne Coimbra +4 more
TL;DR: It is suggested that dysfunction of the GABA-mediated neuronal system in the medial hypothalamus causes panic-like responses in laboratory animals, and that the elaborated escape behaviour organized in both dorsomedial and ventromedial hypothalamic nuclei are followed by significant innate-fear-induced antinociception.
Journal ArticleDOI
Cellular prion protein modulates defensive attention and innate fear-induced behaviour evoked in transgenic mice submitted to an agonistic encounter with the tropical coral snake Oxyrhopus guibei.
Bruno Lobão-Soares,Roger Walz,Roger Walz,Rui Daniel Schroeder Prediger,Renato Leonardo de Freitas,Fabrício Calvo,Marino Muxfeldt Bianchin,Marino Muxfeldt Bianchin,João Pereira Leite,Michele Christine Landemberger,N.C. Coimbra,N.C. Coimbra +11 more
TL;DR: The present findings indicate that the PrP(C) overexpression causes hyperactivity, fearlessness, and increased preference for visual, tactile and olfactory stimuli-associated novelty, and that thePrP(c) deficiency might lead to attention deficits.