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Shuang Huang
Researcher at Georgia Regents University
Publications - 53
Citations - 3525
Shuang Huang is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Cancer & Cell migration. The author has an hindex of 35, co-authored 53 publications receiving 3163 citations. Previous affiliations of Shuang Huang include Shanghai University & Charlie Norwood VA Medical Center.
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Journal Article
ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis (Journal of Biological Chemistry (2008) 283, (6572-6583))
TL;DR: It is shown that ATR is specifically activated during cisplatin treatment and co-localizes with H2AX, forming nuclear foci at the site of DNA damage, suggesting an important role for the DNA damage response mediated by ATR-Chk2 in p53 activation and renal cell apoptosis during cisPlatin nephrotoxicity.
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ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis
TL;DR: In this article, the authors demonstrate an early DNA damage response during cisplatin treatment of renal cells and tissues, and demonstrate a critical role for ATR, but not ATM (ataxia telangiectasia mutated) or DNA-PK (DNA-dependent protein kinase), in the activation and apoptosis of kidney cells.
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The Histone H3 Methyltransferase G9A Epigenetically Activates the Serine-Glycine Synthesis Pathway to Sustain Cancer Cell Survival and Proliferation
Jane Ding,Tai Li,Tai Li,Xiangwei Wang,Erhu Zhao,Erhu Zhao,Jeong Hyeon Choi,Liqun Yang,Yunhong Zha,Zheng Dong,Shuang Huang,John M. Asara,Hongjuan Cui,Han Fei Ding +13 more
TL;DR: It is shown that the histone H3 lysine 9 (H3K9) methyltransferase G9A is required for maintaining the pathway enzyme genes in an active state marked by H3K 9 monomethylation and for the transcriptional activation of this pathway in response to serine deprivation.
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Extracellular Signal–Regulated Kinase Signaling Pathway Regulates Breast Cancer Cell Migration by Maintaining slug Expression
Haoming Chen,Genfeng Zhu,Yong Li,Ravi Padia,Zheng Dong,Zhixing K. Pan,Kebin Liu,Shuang Huang +7 more
TL;DR: The study suggests that the ERK pathway regulates breast cancer cell migration by maintaining slug expression, and an association between ERK-regulated cell migration and slug expression is suggested.
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Ratio of miR-196s to HOXC8 messenger RNA correlates with breast cancer cell migration and metastasis.
Yong Li,Maoxiang Zhang,Huijun Chen,Zheng Dong,Vadivel Ganapathy,Muthusamy Thangaraju,Shuang Huang +6 more
TL;DR: The findings identify miRNA-196s as potent metastasis suppressors and reveal that the ratio of miR- 196s to HOXC8 mRNA might be an indicator of the metastatic capability of breast tumors.