R
René Nieves-Alicea
Researcher at University of Texas MD Anderson Cancer Center
Publications - 16
Citations - 1012
René Nieves-Alicea is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 13, co-authored 16 publications receiving 966 citations. Previous affiliations of René Nieves-Alicea include University of Texas Health Science Center at Houston & University of Puerto Rico, Medical Sciences Campus.
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Journal ArticleDOI
Sustained small interfering RNA delivery by mesoporous silicon particles
Takemi Tanaka,Lingegowda S. Mangala,Pablo E. Vivas-Mejia,René Nieves-Alicea,Aman P. Mann,Edna M. Mora,Edna M. Mora,Hee Dong Han,Mian M.K. Shahzad,Mian M.K. Shahzad,Xuewu Liu,Xuewu Liu,Rohan Bhavane,Jianhua Gu,Jean R. Fakhoury,Jean R. Fakhoury,Ciro Chiappini,Chunhua Lu,Koji Matsuo,Biana Godin,Rebecca L. Stone,Alpa M. Nick,Gabriel Lopez-Berestein,Anil K. Sood,Mauro Ferrari +24 more
TL;DR: The first in vivo therapeutic validation of a novel, multistage siRNA delivery system for sustained gene silencing with broad applicability to pathologies beyond ovarian neoplasms is provided.
Journal ArticleDOI
Identification of thioaptamer ligand against E-selectin: potential application for inflamed vasculature targeting.
Aman P. Mann,Anoma Somasunderam,René Nieves-Alicea,Xin Li,Austin Hu,Anil K. Sood,Mauro Ferrari,David G. Gorenstein,Takemi Tanaka,Takemi Tanaka,Takemi Tanaka +10 more
TL;DR: The discovery of a thioaptamer (ESTA-1) that binds to E-selectin with high affinity and specificity is substantiated, thereby highlighting the potential application of ESTA-1 for E- selectin targeted delivery.
Journal ArticleDOI
In vivo evaluation of safety of nanoporous silicon carriers following single and multiple dose intravenous administrations in mice.
Takemi Tanaka,Biana Godin,Rohan Bhavane,René Nieves-Alicea,Jianhua Gu,Xinming Liu,Ciro Chiappini,Jean R. Fakhoury,S. Amra,A. Ewing,Q. Li,Isaiah J Fidler,Mauro Ferrari,Mauro Ferrari,Mauro Ferrari +14 more
TL;DR: Evidence of a safe intravenous administration of S1MPs as a drug delivery carrier is provided and pSi structures designed as a cargo for nanocarrier drug delivery to enable the loaded therapeutics and diagnostics to sequentially overcome the biological barriers in order to reach their target.
Journal ArticleDOI
Thioaptamer conjugated liposomes for tumor vasculature targeting.
Aman P. Mann,Rohan Bhavane,Anoma Somasunderam,Brenda Liz Montalvo-Ortiz,Ketan B. Ghaghada,David E. Volk,René Nieves-Alicea,K. Stephen Suh,Mauro Ferrari,Ananth Annapragada,David G. Gorenstein,Takemi Tanaka +11 more
TL;DR: This study has developed long circulating liposomes with the outer surface decorated with thioated oligonucleotide aptamer (thioaptamer) against E-selectin (ESTA) and evaluated the targeting efficacy and PK parameters, and opens the door to testing various combinations of thIOaptamer and nanocarriers that can be constructed to target multiple cancer types and tumor components for delivery of both therapeutics and imaging agents.
Journal ArticleDOI
Programmed cell death 4 inhibits breast cancer cell invasion by increasing tissue inhibitor of metalloproteinases-2 expression.
TL;DR: The novel findings that suppression of PDCD4 expression is vital for the invasive activity of COX-2 mediated by PGE2 and IL-8, and that PD CD4 increases TIMP-2 expression to inhibit breast cancer cell invasion are reported.