R
Rohan Bhavane
Researcher at Boston Children's Hospital
Publications - 29
Citations - 2323
Rohan Bhavane is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 17, co-authored 22 publications receiving 2112 citations. Previous affiliations of Rohan Bhavane include Cleveland Clinic & University of Texas Health Science Center at Houston.
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Journal ArticleDOI
Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications
Ennio Tasciotti,Xuewu Liu,Rohan Bhavane,Kevin D. Plant,Ashley D. Leonard,B. Katherine Price,Mark Ming-Cheng Cheng,Paolo Decuzzi,James M. Tour,Fredika M. Robertson,Mauro Ferrari,Mauro Ferrari,Mauro Ferrari +12 more
TL;DR: A multistage delivery system that can carry, release over time and deliver two types of nanoparticles into primary endothelial cells is shown, based on biodegradable and biocompatible mesoporous silicon particles that have well-controlled shapes, sizes and pores.
Journal ArticleDOI
Sustained small interfering RNA delivery by mesoporous silicon particles
Takemi Tanaka,Lingegowda S. Mangala,Pablo E. Vivas-Mejia,René Nieves-Alicea,Aman P. Mann,Edna M. Mora,Edna M. Mora,Hee Dong Han,Mian M.K. Shahzad,Mian M.K. Shahzad,Xuewu Liu,Xuewu Liu,Rohan Bhavane,Jianhua Gu,Jean R. Fakhoury,Jean R. Fakhoury,Ciro Chiappini,Chunhua Lu,Koji Matsuo,Biana Godin,Rebecca L. Stone,Alpa M. Nick,Gabriel Lopez-Berestein,Anil K. Sood,Mauro Ferrari +24 more
TL;DR: The first in vivo therapeutic validation of a novel, multistage siRNA delivery system for sustained gene silencing with broad applicability to pathologies beyond ovarian neoplasms is provided.
Journal ArticleDOI
The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows
Francesco Gentile,Ciro Chiappini,Daniel Fine,Rohan Bhavane,M. S. Peluccio,M. S. Peluccio,Mark Ming-Cheng Cheng,Xuewu Liu,Mauro Ferrari,Mauro Ferrari,Paolo Decuzzi,Paolo Decuzzi +11 more
TL;DR: The margination dynamics of microparticles with different shapes has been analyzed within a laminar flow mimicking the hydrodynamic conditions in the microcirculation, showing discoidal particles marginate in a larger number compared to quasi-hemispherical and spherical particles.
Journal ArticleDOI
The association of silicon microparticles with endothelial cells in drug delivery to the vasculature.
Rita E. Serda,Jianhua Gu,Rohan Bhavane,Xuewu Liu,Ciro Chiappini,Paolo Decuzzi,Mauro Ferrari,Mauro Ferrari,Mauro Ferrari +8 more
TL;DR: These findings suggest that it may be possible to bioengineer silicon microparticles to favor opsonization with proteins that enhance uptake by endothelial cells, without a concurrent enhanced uptake by macrophages.
Journal ArticleDOI
Indocyanine green fluorescence in second near-infrared (NIR-II) window.
Zbigniew Starosolski,Rohan Bhavane,Ketan B. Ghaghada,Sanjeev A. Vasudevan,Alexander Kaay,Ananth Annapragada +5 more
TL;DR: In vivo imaging further confirmed the utility of ICG as a fluorescent dye in the NIR-II domain, with the CNR values being ~2 times those in theNIR-I window.