P
Pablo E. Vivas-Mejia
Researcher at University of Puerto Rico
Publications - 70
Citations - 3074
Pablo E. Vivas-Mejia is an academic researcher from University of Puerto Rico. The author has contributed to research in topics: Ovarian cancer & Cancer. The author has an hindex of 27, co-authored 58 publications receiving 2589 citations. Previous affiliations of Pablo E. Vivas-Mejia include University of Texas MD Anderson Cancer Center & University of Puerto Rico, Río Piedras.
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Journal ArticleDOI
Sustained small interfering RNA delivery by mesoporous silicon particles
Takemi Tanaka,Lingegowda S. Mangala,Pablo E. Vivas-Mejia,René Nieves-Alicea,Aman P. Mann,Edna M. Mora,Edna M. Mora,Hee Dong Han,Mian M.K. Shahzad,Mian M.K. Shahzad,Xuewu Liu,Xuewu Liu,Rohan Bhavane,Jianhua Gu,Jean R. Fakhoury,Jean R. Fakhoury,Ciro Chiappini,Chunhua Lu,Koji Matsuo,Biana Godin,Rebecca L. Stone,Alpa M. Nick,Gabriel Lopez-Berestein,Anil K. Sood,Mauro Ferrari +24 more
TL;DR: The first in vivo therapeutic validation of a novel, multistage siRNA delivery system for sustained gene silencing with broad applicability to pathologies beyond ovarian neoplasms is provided.
Journal ArticleDOI
Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis
Anil K. Sood,Guillermo N. Armaiz-Pena,Jyotsnabaran Halder,Alpa M. Nick,Rebecca L. Stone,Wei Hu,Amy R. Carroll,Whitney A. Spannuth,Michael T. Deavers,Julie K. Allen,Liz Y. Han,Aparna A. Kamat,Mian M.K. Shahzad,Bradley W. McIntyre,Claudia M. Diaz-Montero,Nicholas B. Jennings,Yvonne G. Lin,William M. Merritt,Koen DeGeest,Pablo E. Vivas-Mejia,Gabriel Lopez-Berestein,Michael D. Schaller,Steven W. Cole,Susan K. Lutgendorf +23 more
TL;DR: It is demonstrated that human ovarian cancer cells exposed to either norepinephrine or epinephrine exhibit lower levels of anoikis, the process by which cells enter apoptosis when separated from ECM and neighboring cells, and FAK modulation by stress hormones can contribute to tumor progression in patients with ovarian cancer.
Journal ArticleDOI
Src activation by adrenoreceptors is a key switch for tumour metastasis
Guillermo N. Armaiz-Pena,Julie K. Allen,Julie K. Allen,Anthony Cruz,Rebecca L. Stone,Alpa M. Nick,Yvonne G. Lin,Liz Y. Han,Lingegowda S. Mangala,Gabriel J. Villares,Gabriel J. Villares,Pablo E. Vivas-Mejia,Pablo E. Vivas-Mejia,Cristian Rodriguez-Aguayo,Archana S. Nagaraja,Archana S. Nagaraja,Kshipra M. Gharpure,Kshipra M. Gharpure,Zheng Wu,Robert D. English,Kizhake V. Soman,Mian M.K. Shahzad,Maya Zigler,Maya Zigler,Michael T. Deavers,Alexander Zien,Theodoros G. Soldatos,David B. Jackson,John E. Wiktorowicz,Madeline Torres-Lugo,Tom Young,Koen De Geest,Gary E. Gallick,Menashe Bar-Eli,Gabriel Lopez-Berestein,Steve W. Cole,Gustavo E. López,Susan K. Lutgendorf,Anil K. Sood +38 more
TL;DR: These results identify a new mechanism of Src phosphorylation that mediates beta-adrenergic/PKA regulation of downstream networks, thereby enhancing tumor cell migration, invasion and growth and provide a pivotal molecular target for disrupting neural signaling in the tumor microenvironment.
Journal ArticleDOI
Targeting melanoma growth and metastasis with systemic delivery of liposome-incorporated protease-activated receptor-1 small interfering RNA
Gabriel J. Villares,Maya Zigler,Hua Wang,Vladislava O. Melnikova,Hong Wu,Ran Friedman,Michael C. Leslie,Pablo E. Vivas-Mejia,Gabriel Lopez-Berestein,Anil K. Sood,Menashe Bar-Eli +10 more
TL;DR: It is proposed that siRNA incorporated into DOPC nanoparticles could be delivered systemically and used as a new modality for melanoma treatment and stably silence PAR-1 through the use of lentiviral short hairpin RNA.
Journal ArticleDOI
Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasis
Mian M.K. Shahzad,Jesusa M.G. Arevalo,Guillermo N. Armaiz-Pena,Chunhua Lu,Rebecca L. Stone,Myrthala Moreno-Smith,Masato Nishimura,Jeong Won Lee,Jeong Won Lee,Nicholas B. Jennings,Justin Bottsford-Miller,Pablo E. Vivas-Mejia,Susan K. Lutgendorf,Gabriel Lopez-Berestein,Menashe Bar-Eli,Steven W. Cole,Anil K. Sood +16 more
TL;DR: The findings indicate that neurobehavioral stress leads to FosB-driven increases in IL8, which is associated with increased tumor growth and metastases, which may have implications for ovarian cancer management.