Renee Risingsong

TL;DR: This work shows that synthetic triterpenoid analogues of oleanolic acid are extremely potent inducers of the phase 2 response [e.g., elevation of NAD(P)H-quinone oxidoreductase and heme oxygenase 1], which is a major protector of cells against oxidative and electrophile stress.

TL;DR: These studies are the first to investigate the induction of the HO-1 and Nrf2/ARE pathways by CDDO and CDDO-Im, and the results suggest that further in vivo studies are needed to explore the chemopreventive and chemotherapeutic potential of the triterpenoids.

TL;DR: This is the first report of the use of a ligand for peroxisome proliferator-activated receptor-gamma to prevent experimental breast cancer.

TL;DR: Two triterpenoid compounds that activate the Nrf2/ARE signaling pathway may be useful in the treatment of ALS and significantly attenuated weight loss, enhanced motor performance, and extended the survival of G93A SOD1 mice.

TL;DR: The potent effects of CDDO-Im, both in vitro and in vivo, suggest it should be considered for clinical use and de novo inducible nitric oxide synthase expression in primary mouse macrophages.