R
Ri Yao Yang
Researcher at University of Texas MD Anderson Cancer Center
Publications - 36
Citations - 3932
Ri Yao Yang is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Galectin & Immunotherapy. The author has an hindex of 20, co-authored 33 publications receiving 3358 citations. Previous affiliations of Ri Yao Yang include Scripps Research Institute & La Jolla Institute for Allergy and Immunology.
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Journal ArticleDOI
Expression of galectin-3 modulates T-cell growth and apoptosis
TL;DR: Galectin-3 is a regulator of cell growth and apoptosis and it may function through a cell death inhibition pathway that involves Bcl-2, a well-characterized suppressor of apoptosis.
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Galectins: structure, function and therapeutic potential.
TL;DR: Current research indicates that galectins play important roles in diverse physiological and pathological processes, including immune and inflammatory responses, tumour development and progression, neural degeneration, atherosclerosis, diabetes, and wound repair, and may be a therapeutic target or employed as therapeutic agents for inflammatory diseases, cancers and several other diseases.
Journal ArticleDOI
Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses.
Daniel K. Hsu,Ri Yao Yang,Zhixing Pan,Lan Yu,Daniel R. Salomon,Wai-Ping Fung-Leung,Fu-Tong Liu +6 more
TL;DR: It was found that peritoneal macrophages from gal3(-/-) mice were more prone to undergo apoptosis than those from Gal3(+/+) mice when treated with apoptotic stimuli, suggesting that expression of galectin-3 in inflammatory cells may lead to longer cell survival, thus prolonging inflammation.
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Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release.
Ichiro Kuwabara,Yasuko Kuwabara,Ri Yao Yang,Martin Schuler,Douglas R. Green,Bruce L. Zuraw,Daniel K. Hsu,Daniel K. Hsu,Fu-Tong Liu +8 more
TL;DR: Transfectants of HeLa and DLD-1 cells ectopically expressing galectin-7 were found to be more susceptible to apoptosis than control transfectants and this protein is a pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.
Journal ArticleDOI
Galectins in cell growth and apoptosis
Ri Yao Yang,Fu-Tong Liu +1 more
TL;DR: Fourteen members of the galectin family, proteins with conserved carbohydrate-recognition domains that bind β-galactoside, have been cloned and more are expected to be discovered in the near future, with the only member known so far to inhibit apoptosis.