R
Ricard Masia
Researcher at Harvard University
Publications - 72
Citations - 2338
Ricard Masia is an academic researcher from Harvard University. The author has contributed to research in topics: Fibrosis & Sulfonylurea receptor. The author has an hindex of 23, co-authored 65 publications receiving 1609 citations. Previous affiliations of Ricard Masia include Brigham and Women's Hospital & Washington University in St. Louis.
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Journal ArticleDOI
Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis
Xiaobo Wang,Ze Zheng,Jorge Matias Caviglia,Kathleen E. Corey,Tina M. Herfel,Bishuang Cai,Ricard Masia,Raymond T. Chung,Jay H. Lefkowitch,Robert F. Schwabe,Ira Tabas +10 more
TL;DR: It is shown that the transcription regulator TAZ (WWTR1) is markedly higher in hepatocytes in human and murine NASH liver than in normal or steatotic liver, and represents a previously unrecognized factor that contributes to the critical process of steatosis-to-NASH progression.
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Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma
James S. V. Lally,Sarani Ghoshal,Danielle K. DePeralta,Omeed Moaven,Lan Wei,Ricard Masia,Derek J. Erstad,Naoto Fujiwara,Vivian Leong,Vanessa P. Houde,Alexander E. Anagnostopoulos,Alice Wang,Lindsay A. Broadfield,Rebecca J. Ford,Robert A. Foster,Jamie Bates,Hailing Sun,Ting Wang,Henry Liu,Adrian S. Ray,Asish K. Saha,Jeremy R. Greenwood,Sathesh Bhat,Geraldine Harriman,Wenyan Miao,Jennifer Rocnik,William F. Westlin,Paola Muti,Theodoros Tsakiridis,H. James Harwood,Rosana Kapeller,Yujin Hoshida,Kenneth K. Tanabe,Gregory R. Steinberg,Bryan C. Fuchs +34 more
TL;DR: A novel, liver-specific ACC inhibitor that mimics the effects of ACC phosphorylation inhibits hepatic DNL and the development of HCC, improving survival of tumor-bearing rats when used alone and in combination with the multi-kinase inhibitor sorafenib.
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Histopathologic features of colitis due to immunotherapy With Anti-PD-1 antibodies
TL;DR: In patients who experienced recurrence of anti-PD-1 colitis, histologic features were similar to the initial insult but, in addition, features of chronicity developed that mimicked inflammatory bowel disease (basal lymphoplasmacytosis and crypt architectural irregularity, and Paneth cell metaplasia in 1 case).
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Differential Structure of Atrial and Ventricular KATP Atrial KATP Channels Require SUR1
Thomas P. Flagg,Harley T. Kurata,Ricard Masia,George Caputa,Mark A. Magnuson,David J. Lefer,William A. Coetzee,Colin G. Nichols +7 more
TL;DR: Differential molecular make-up of the 2 channels underlies differential pharmacology, with important implications when considering sulfonylurea therapy or dissecting the role of cardiac KATP pharmacologically, as well as for understanding of the roles of diazoxide in preconditioning.
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Gastrointestinal biopsy findings of autoimmune enteropathy: a review of 25 cases
TL;DR: In summary, AIE most commonly presents as an active enteritis with villous blunting and expansion of the lamina propria by mixed inflammation, and biopsies from sites other than the small intestine may greatly facilitate its diagnosis.