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Richard A. Radcliffe
Researcher at University of Montana
Publications - 67
Citations - 2172
Richard A. Radcliffe is an academic researcher from University of Montana. The author has contributed to research in topics: Quantitative trait locus & Gene. The author has an hindex of 25, co-authored 67 publications receiving 1921 citations. Previous affiliations of Richard A. Radcliffe include University of Colorado Boulder & University of Colorado Denver.
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Journal ArticleDOI
The multiMiR R package and database: integration of microRNA–target interactions along with their disease and drug associations
Yuanbin Ru,Katerina Kechris,Boris Tabakoff,Paula L. Hoffman,Richard A. Radcliffe,Russell P. Bowler,Spencer Mahaffey,Simona Rossi,George A. Calin,Lynne T. Bemis,Dan Theodorescu +10 more
TL;DR: MultiMiR is presented, a new miRNA–target interaction R package and database, which includes several novel features not available in existing R packages and was used to generate testable hypotheses that were pursued experimentally.
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Quantitative trait locus analysis of contextual fear conditioning in mice
Jeanne M. Wehner,Richard A. Radcliffe,Shelby T. Rosmann,Steven C. Christensen,Duffy L. Rasmussen,David W. Fulker,Michelle Wiles +6 more
TL;DR: A quantitative trait locus (QTL) analysis of contextual fear conditioning was performed in a B6/D2 F2 intercross population of mice, finding evidence for a substantial genetic component underlying individual differences in general intelligence, specific cognitive abilities and susceptibility to psychopathologies related to fear-inducing events.
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The Role of RNA Editing of Kainate Receptors in Synaptic Plasticity and Seizures
Bryce Vissel,Gordon Royle,Brian R. Christie,Hans H. Schiffer,Andrea Ghetti,Theresa Tritto,Isabel Pérez-Otaño,Richard A. Radcliffe,Jeremy K. Seamans,Terrence J. Sejnowski,Jeanne M. Wehner,Allan C. Collins,Stephen O'Gorman,Steve Heinemann +13 more
TL;DR: Results suggest that GluR6 Q/R site RNA editing may modulate synaptic plasticity and seizure vulnerability and suggest that NMDA receptor-independent long-term potentiation could be induced at the medial perforant path-dentate gyrus synapse.
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Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3.
Alpna Tyagi,Rana P. Singh,Kumaraguruparan Ramasamy,Komal Raina,Elizabeth F. Redente,Lori D. Dwyer-Nield,Richard A. Radcliffe,Alvin M. Malkinson,Rajesh Agarwal +8 more
TL;DR: Therapeutic efficacy of silibinin in lung tumor growth inhibition and regression by antiangiogenic mechanisms seem to be mediated by decreased tumor-associated macrophages and cytokines, inhibition of hypoxia-inducible factor-1α, NF-κB, and STAT-3 activation, and up-regulation of the angiogenic inhibitors, Ang-2 and Tie-2.
Journal ArticleDOI
Contextual and cued fear conditioning in C57BL/6J and DBA/2J mice: context discrimination and the effects of retention interval.
TL;DR: Context discrimination and time course studies of contextual fear conditioning revealed strain differences between C57BL/6J (B6) and DBA/2J (D2) mice, which confirmed that B6, but not D2, mice retained contextual memories for at least 60 days.