Richard Clark

TL;DR: Data show that AP-3 is essential for polarized secretion from CTLs, and an HPS2 mutation leads to a loss of cytotoxic T lymphocyte (CTL)-mediated cytotoxicity.

TL;DR: A proline-rich domain (PRD) in the cytoplasmic tail of FasL that is responsible for sorting FasL to secretory lysosomes is defined and an interaction of the PRD of Fasl with an SH3-domain-containing protein, enables direct sorting of Fas L from the Golgi tosecretory l Lysosomes.

TL;DR: The genetically heterogeneous Hermansky-Pudlak syndrome represents an excellent model for revealing proteins involved in secretory lysosome functioning, however, studies of this disease reveal differences between the various different types of secretoryLysosomes, including lytic granules.

TL;DR: The combined use of confocal and electron microscopy has produced some surprising findings, which suggest that the secretory synapse may be important both in delivering the lethal hit and in facilitating membrane transfer from target to CTL.

TL;DR: Examination of cytotoxic T‐lymphocyte (CTL) secretion from two BLOC‐3‐deficient patients and seven different mouse models of Hermansky–Pudlak syndrome reveals differences in the protein machinery required for biogenesis and/or secretion of lysosome‐related organelles in CTL and melanocytes.