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Esteban C. Dell'Angelica
Researcher at University of California, Los Angeles
Publications - 92
Citations - 8380
Esteban C. Dell'Angelica is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Biogenesis & Protein subunit. The author has an hindex of 43, co-authored 85 publications receiving 7726 citations. Previous affiliations of Esteban C. Dell'Angelica include Semel Institute for Neuroscience and Human Behavior & National Institutes of Health.
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Journal ArticleDOI
Altered Trafficking of Lysosomal Proteins in Hermansky-Pudlak Syndrome Due to Mutations in the β3A Subunit of the AP-3 Adaptor
Esteban C. Dell'Angelica,Vorasuk Shotelersuk,Ruben C. Aguilar,William A. Gahl,Juan S. Bonifacino +4 more
TL;DR: The results suggest that AP-3 functions in protein sorting to lysosomes and provide an example of a human disease in which altered trafficking of integral membrane proteins is due to mutations in a component of the sorting machinery.
Journal ArticleDOI
Lysosome-related organelles
TL;DR: Identification of genes mutated in these human diseases, as well as in mouse and Drosophila pigmentation mutants, is beginning to shed light on the molecular machinery involved in the biogenesis of lysosomes and lysOSome‐related organelles.
Journal ArticleDOI
Molecular bases for the recognition of tyrosine-based sorting signals.
TL;DR: Targeting of transmembrane proteins to different compartments of the endocytic and late (post-Golgi) secretory pathways is largely dependent upon sorting signals contained within the cytosolic domains of the proteins.
Journal ArticleDOI
Ggas A Family of Adp Ribosylation Factor-Binding Proteins Related to Adaptors and Associated with the Golgi Complex
Esteban C. Dell'Angelica,Rosa Puertollano,Chris Mullins,Ruben C. Aguilar,Jose D. Vargas,Lisa M. Hartnell,Juan S. Bonifacino +6 more
TL;DR: Observations suggest that GGAs are components of ARF-regulated coats that mediate protein trafficking at the TGN, which includes three members in humans and two in yeast.
Journal ArticleDOI
Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).
Wei Li,Qing Zhang,Naoki Oiso,Edward K. Novak,Rashi Gautam,Edward P. O'Brien,Caroline L. Tinsley,Derek J. Blake,Richard A. Spritz,Neal G. Copeland,Nancy A. Jenkins,Dominick Amato,Bruce A. Roe,Marta Starcevic,Esteban C. Dell'Angelica,Rosemary W. Elliott,Vishnu S. Mishra,Stephen F. Kingsmore,Richard Paylor,Richard T. Swank +19 more
TL;DR: It is shown that BLOC-1 is important in producing the HPS phenotype in humans, it is indicated that dysbindin has a role in the biogenesis of lysosome-related organelles and unexpected interactions between components of DPC and BL OC-1 are identified.