Richard D.R. Camp

TL;DR: The results of this genome wide analysis demonstrate that, at least in the population studied, a gene or genes located within the MHC and close to the class 1 HLA loci represent the major determinant of the genetic basis of psoriasis.

TL;DR: The results demonstrate the potential importance of type I collagen, an abundant extracellular matrix protein, in enhancing the activation of extravascular effector T cells in inflammatory disease, and point to a new immunotherapeutic target.

TL;DR: The hypothesis that S. pyogenes infections are more important in the pathogenesis of chronic plaque psoriasis than has previously been recognized is justified, and the need for further controlled therapeutic trials of antibacterial measures in this common skin disease is indicated.

TL;DR: The presence of IgG in upper lesional epidermis is confirmed and high-resolution two-dimensional immunoblotting of extracts from this tissue and laser desorption mass spectrometry of tryptic peptides are used to define a series of epidermal proteins that bind IgG from psoriatic serum.

TL;DR: Findings suggest that hypersensitivity to Dp might be clinically relevant in approximately one third of the adult atopic dermatitis population studied and point to methods of identifying patients who might respond to house dust avoidance measures.