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Angela J. Frodsham
Researcher at Wellcome Trust Centre for Human Genetics
Publications - 28
Citations - 3411
Angela J. Frodsham is an academic researcher from Wellcome Trust Centre for Human Genetics. The author has contributed to research in topics: Hepatitis C virus & Population. The author has an hindex of 19, co-authored 28 publications receiving 3268 citations. Previous affiliations of Angela J. Frodsham include University of Leicester & University of Cambridge.
Papers
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Journal ArticleDOI
Automated binning of microsatellite alleles: problems and solutions
TL;DR: This work introduces a method that allows repeat units to be fractionally shorter or longer than their theoretical value, and performs well over a wide range of dinucleotide repeat loci.
Journal ArticleDOI
Identification of a Major Susceptibility Locus on Chromosome 6p and Evidence for Further Disease Loci Revealed by a Two Stage Genome-Wide Search in Psoriasis
Richard C. Trembath,R. Lee Clough,Jane L. Rosbotham,Jane L. Rosbotham,Andrew B. Jones,Richard D.R. Camp,Angela J. Frodsham,Julie Browne,Ruth C. Barber,Joseph D. Terwilliger,Joseph D. Terwilliger,G. Mark Lathrop,Jonathan Barker +12 more
TL;DR: The results of this genome wide analysis demonstrate that, at least in the population studied, a gene or genes located within the MHC and close to the class 1 HLA loci represent the major determinant of the genetic basis of psoriasis.
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A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.
Chiea Chuen Khor,Stephen J Chapman,Stephen J Chapman,Fredrik O. Vannberg,Aisling Dunne,Caroline Murphy,Edmund Y. S. Ling,Angela J. Frodsham,Andrew Walley,Andrew Walley,Otto Kyrieleis,Amir R. Khan,Christophe Aucan,Shelley Segal,Catrin E. Moore,Kyle Knox,Sarah J. Campbell,Christian Lienhardt,Anthony Scott,Peter Aaby,Oumou Sow,Robert T Grignani,Robert T Grignani,Jackson Sillah,Giorgio Sirugo,N Peshu,Thomas N. Williams,Kathryn Maitland,Robert J. O. Davies,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Nicholas P. J. Day,Djamel Yala,Derrick W. Crook,Kevin Marsh,James A. Berkley,Luke A. J. O'Neill,Adrian V. S. Hill +38 more
TL;DR: In this paper, a case-control study of 6,106 individuals from the UK, Vietnam and several African countries with invasive pneumococcal disease, bacteremia, malaria and tuberculosis was conducted.
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Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR
S Knapp,Leland J. Yee,Leland J. Yee,Angela J. Frodsham,Branwen J. Hennig,Simon Hellier,Lyna Zhang,M. Wright,Maria Chiaramonte,Mary C. Graves,Howard C. Thomas,A V S Hill,Mark Thursz +12 more
TL;DR: Polymorphisms in the interferon-induced genes, MxA, OAS-1 and PKR appear thus associated with HCV outcome.
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Association of Vitamin D Receptor Genotype with Leprosy Type
TL;DR: This study suggests that the VDR polymorphism may influence susceptibility to some diseases by affecting the type and the strength of the host immune response.