Showing papers by "Richard Durbin published in 1988"
TL;DR: A genome mapping package has been developed for reading and assembling data from clones analysed by restriction enzyme fragmentation and polyacrylamide gel electrophoresis to meet the needs of the Caenorhabditis project.
Abstract: A genome mapping package has been developed for reading and assembling data from clones analysed by restriction enzyme fragmentation and polyacrylamide gel electrophoresis. The package comprises: data entry; matching; assembly; statistical analysis; modelling. Data entry can be either manual or by a semiautomatic system based on a scanning densitometer. The primary emphasis in the analytical routines is on flexibility and interactive convenience, so that the operator has full knowledge of and control over the growing map, but a variety of automatic options are included. The package continually grows to meet the needs of the Caenorhabditis project.
132 citations
TL;DR: Used in conjunction with fluorescent voltage-sensitive or ion-sensitive dyes, confocal microscopy may make possible a wide range of investigations of brain function and plasticity that were difficult or impossible with previous techniques.
115 citations