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Richard E. Fine
Researcher at Boston University
Publications - 118
Citations - 5828
Richard E. Fine is an academic researcher from Boston University. The author has contributed to research in topics: Vesicle & Receptor. The author has an hindex of 42, co-authored 118 publications receiving 5636 citations. Previous affiliations of Richard E. Fine include University of California, Irvine & Laboratory of Molecular Biology.
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Receptor-mediated transcytosis of transferrin across the blood-brain barrier.
TL;DR: The perfusion of rat brain with 125I‐transferrin resulted in a receptor‐mediated uptake of transferrin into the endothelium of the blood‐brain barrier followed by its detecation in the brain, suggesting that the brain may derive its iron through the transcytosis of iron‐loaded transferrin across the brain microvasculature.
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Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.
Mina Yaar,S Zhai,Paul F. Pilch,Sineaid M. Doyle,Patricia B. Eisenhauer,Richard E. Fine,Barbara A. Gilchrest +6 more
TL;DR: Using rat cortical neurons and NIH-3T3 cell line engineered to stably express p75NTR, it is found that the beta-amyloid peptide specifically binds the p75 NTR, implying that neuronal death in Alzheimer's disease is mediated, at least in part, by the interaction of beta- amyloid with p 75NTR.
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Non-age Related Differences in Thrombin Responses by Platelets from Male Patients with Advanced Alzheimer′s Disease
Theresa A. Davies,Richard E. Fine,Robin J. Johnson,C.A Levesque,W.H. Rathbun,Kurt F. Seetoo,Sally J. Smith,G. Strohmeier,L. Volicer,L. Delva,Elizabeth R. Simons +10 more
TL;DR: It is shown here that platelets from patients with severe AD have abnormal stimulus responses to alpha-thrombin, and these cells hyperacidify, which may contribute to aberrant granule secretion.
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Coated vesicles transport newly synthesized membrane glycoproteins from endoplasmic reticulum to plasma membrane in two successive stages
James E. Rothman,Richard E. Fine +1 more
TL;DR: The G protein of vesicular stomatitis virus is a transmembrane glycoprotein that is transported from its site of synthesis in the rough endoplasmic reticulum to the plasma membrane via the Golgi apparatus as discussed by the authors.
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Evidence that coated vesicles isolated from brain are calcium-sequestering organelles resembling sarcoplasmic reticulum.
TL;DR: Coated vesicles from the brain have been purified to near morphological homogeneity by a modification of the method of Pearse, and the possible functions of coated vesicle as calcium-sequestering organelles are discussed.