J
Joshua B. Rubin
Researcher at Washington University in St. Louis
Publications - 214
Citations - 12850
Joshua B. Rubin is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Medicine & Glioma. The author has an hindex of 53, co-authored 180 publications receiving 10221 citations. Previous affiliations of Joshua B. Rubin include Harvard University & St. Louis Children's Hospital.
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Journal ArticleDOI
Sex and gender: modifiers of health, disease, and medicine.
Franck Mauvais-Jarvis,Noel Bairey Merz,Peter J. Barnes,Roberta Diaz Brinton,Juan Jesus Carrero,Dawn L. DeMeo,Geert J. De Vries,C. Neill Epperson,Ramaswamy Govindan,Sabra L. Klein,Amedeo Lonardo,Pauline M. Maki,Louise D. McCullough,Vera Regitz-Zagrosek,Vera Regitz-Zagrosek,Judith G. Regensteiner,Joshua B. Rubin,Kathryn Sandberg,Ayako Suzuki,Ayako Suzuki +19 more
TL;DR: Clinicians and researchers are guided to consider sex and gender in their approach to diagnosis, prevention, and treatment of diseases as a necessary and fundamental step towards precision medicine, which will benefit men's and women's health.
Journal ArticleDOI
Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Paul A. Northcott,Paul A. Northcott,David Shih,John Peacock,Livia Garzia,A. Sorana Morrissy,Thomas Zichner,Adrian M. Stütz,Andrey Korshunov,Jüri Reimand,Steven E. Schumacher,Rameen Beroukhim,Rameen Beroukhim,David W. Ellison,Christian R. Marshall,Anath C. Lionel,Stephen C. Mack,Adrian M. Dubuc,Yuan Yao,Vijay Ramaswamy,Betty Luu,Adi Rolider,Florence M.G. Cavalli,Xin Wang,Marc Remke,Xiaochong Wu,Readman Chiu,Andy Chu,Eric Chuah,Richard Corbett,Gemma Hoad,Shaun D. Jackman,Yisu Li,Allan Lo,Karen Mungall,Ka Ming Nip,Jenny Q. Qian,Anthony Raymond,Nina Thiessen,Richard Varhol,Inanc Birol,Richard A. Moore,Andrew J. Mungall,Robert A. Holt,Daisuke Kawauchi,Martine F. Roussel,Marcel Kool,David T.W. Jones,Hendrick Witt,Africa Fernandez-L,Anna Kenney,Robert J. Wechsler-Reya,Peter B. Dirks,Tzvi Aviv,Wiesława Grajkowska,Marta Perek-Polnik,Christine Haberler,Olivier Delattre,Stéphanie Reynaud,François Doz,Sarah S. Pernet-Fattet,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Wolfram Scheurlen,Charles G. Eberhart,Michelle Fèvre-Montange,Anne Jouvet,Ian F. Pollack,Xing Fan,Karin M. Muraszko,G. Yancey Gillespie,Concezio Di Rocco,Luca Massimi,Erna M.C. Michiels,Nanne K. Kloosterhof,Pim J. French,Johan M. Kros,James M. Olson,Richard G. Ellenbogen,Karel Zitterbart,Leos Kren,Reid C. Thompson,Michael K. Cooper,Boleslaw Lach,Boleslaw Lach,Roger E. McLendon,Darell D. Bigner,Adam M. Fontebasso,Steffen Albrecht,Steffen Albrecht,Nada Jabado,Janet C. Lindsey,Simon Bailey,Nalin Gupta,William A. Weiss,László Bognár,Almos Klekner,Timothy E. Van Meter,Toshihiro Kumabe,Teiji Tominaga,Samer K. Elbabaa,Jeffrey R. Leonard,Joshua B. Rubin,Linda M. Liau,Erwin G. Van Meir,Maryam Fouladi,Hideo Nakamura,Giuseppe Cinalli,Miklós Garami,Peter Hauser,Ali G. Saad,Achille Iolascon,Shin Jung,Carlos Gilberto Carlotti,Rajeev Vibhakar,Young Shin Ra,Shenandoah Robinson,Massimo Zollo,Claudia C. Faria,Jennifer A. Chan,Michael J. Levy,Poul H. Sorensen,Matthew Meyerson,Scott L. Pomeroy,Yoon Jae Cho,Gary D. Bader,Uri Tabori,Cynthia Hawkins,Eric Bouffet,Stephen W. Scherer,James T. Rutka,David Malkin,Steven C. Clifford,Steven J.M. Jones,Jan O. Korbel,Stefan M. Pfister,Stefan M. Pfister,Marco A. Marra,Michael D. Taylor +139 more
TL;DR: Somatic copy number aberrations (SCNAs) in 1,087 unique medulloblastomas are reported, including recurrent events targeting TGF-β signalling in Group 3, and NF-κB signalling in Groups 4, which suggest future avenues for rational, targeted therapy.
Journal ArticleDOI
Intertumoral Heterogeneity within Medulloblastoma Subgroups
Florence M.G. Cavalli,Marc Remke,Marc Remke,Marc Remke,Ladislav Rampášek,John Peacock,David Shih,Betty Luu,Livia Garzia,Jonathon Torchia,Carolina Nor,A. Sorana Morrissy,Sameer Agnihotri,Yuan Yao Thompson,Claudia M. Kuzan-Fischer,Hamza Farooq,Keren Isaev,Keren Isaev,Craig Daniels,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Ji Yeoun Lee,Wiesława Grajkowska,Marta Perek-Polnik,Alexandre Vasiljevic,Cécile Faure-Conter,Anne Jouvet,Caterina Giannini,Amulya A. Nageswara Rao,Kay Ka Wai Li,Ho Keung Ng,Charles G. Eberhart,Ian F. Pollack,Ronald L. Hamilton,G. Yancey Gillespie,James M. Olson,James M. Olson,Sarah Leary,William A. Weiss,Boleslaw Lach,Boleslaw Lach,Lola B. Chambless,Reid C. Thompson,Michael K. Cooper,Rajeev Vibhakar,Peter Hauser,Marie Lise C. van Veelen,Johan M. Kros,Pim J. French,Young Shin Ra,Toshihiro Kumabe,Enrique López-Aguilar,Karel Zitterbart,Jaroslav Sterba,Gaetano Finocchiaro,Maura Massimino,Erwin G. Van Meir,Satoru Osuka,Tomoko Shofuda,Almos Klekner,Massimo Zollo,Jeffrey R. Leonard,Joshua B. Rubin,Nada Jabado,Steffen Albrecht,Steffen Albrecht,Jaume Mora,Timothy E. Van Meter,Shin Jung,Andrew S. Moore,Andrew R. Hallahan,Jennifer A. Chan,Daniela Pretti da Cunha Tirapelli,Carlos Gilberto Carlotti,Maryam Fouladi,José Pimentel,Claudia C. Faria,Ali G. Saad,Luca Massimi,Linda M. Liau,Helen Wheeler,Hideo Nakamura,Samer K. Elbabaa,Mario Perezpeña-Diazconti,Fernando Chico Ponce de León,Shenandoah Robinson,Michal Zapotocky,Alvaro Lassaletta,Annie Huang,Cynthia Hawkins,Uri Tabori,Eric Bouffet,Ute Bartels,Peter B. Dirks,James T. Rutka,Gary D. Bader,Jüri Reimand,Jüri Reimand,Anna Goldenberg,Vijay Ramaswamy,Michael D. Taylor +101 more
TL;DR: Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes.
Journal ArticleDOI
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors
Joshua B. Rubin,Andrew L. Kung,Robyn S. Klein,Jennifer A. Chan,Yanping Sun,Karl Schmidt,Mark W. Kieran,Andrew D. Luster,Rosalind A. Segal +8 more
TL;DR: It is demonstrated that activation of the Gi protein-coupled receptor CXCR4 is critical for the growth of both malignant neuronal and glial tumors and provided a scientific rationale for clinical evaluation of AMD 3100 in treating both adults and children with malignant brain tumors.
Journal ArticleDOI
Receptor-mediated transcytosis of transferrin across the blood-brain barrier.
TL;DR: The perfusion of rat brain with 125I‐transferrin resulted in a receptor‐mediated uptake of transferrin into the endothelium of the blood‐brain barrier followed by its detecation in the brain, suggesting that the brain may derive its iron through the transcytosis of iron‐loaded transferrin across the brain microvasculature.