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Richard J. Mannion
Researcher at Harvard University
Publications - 32
Citations - 4687
Richard J. Mannion is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Dorsal root ganglion. The author has an hindex of 17, co-authored 21 publications receiving 4508 citations. Previous affiliations of Richard J. Mannion include University College London.
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Journal ArticleDOI
Neuropathic pain: aetiology, symptoms, mechanisms, and management
TL;DR: This work highlights current theories about peripheral neuropathic pain and shows that progress in management is contingent on targeting treatment not at the aetiological factors or the symptoms but at the mechanisms that operate to produce the symptoms.
Journal ArticleDOI
Neurotrophins: Peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity
Richard J. Mannion,Michael Costigan,Isabelle Decosterd,Fumimasa Amaya,Qing-Ping Ma,J. C. Holstege,Ru-Rong Ji,A. Acheson,Ronald M. Lindsay,G. A. Wilkinson,Clifford J. Woolf +10 more
TL;DR: BDNF, by virtue of its nerve growth factor regulation in sensory neurons including novel expression in A fibers, has a role as a central modulator of tactile stimulus-induced inflammatory pain hypersensitivity.
Journal ArticleDOI
Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons.
Simon Tate,Susanna C. Benn,Caroline Anne Hick,Derek J. Trezise,Victoria H John,Richard J. Mannion,Richard J. Mannion,Michael Costigan,Chris Plumpton,David Grose,Zoe Gladwell,Giles S Kendall,Katie Dale,C. Bountra,Clifford J. Woolf,Clifford J. Woolf +15 more
TL;DR: It is shown that SNS2 expression in HEK293T cells produced a TTX-R voltage-gated sodium current with faster kinetics and a lower TTX IC50 than the previously cloned sensory-neuron-specific sodium channel, SNS/PN3.
Journal ArticleDOI
Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2
Fumimasa Amaya,Isabelle Decosterd,Tarek A. Samad,C Plumpton,Simon Tate,Richard J. Mannion,Michael Costigan,Clifford J. Woolf +7 more
TL;DR: The differential distribution of two tetrodotoxin resistant (TTXr) voltage-gated sodium channels SNS (PN3) and SNS2 (NaN) in rat primary sensory neurons has been investigated and at least four different classes of A- and C-fiber DRG neurons exist, therefore, with respect to expression of these sodium channels.
Journal ArticleDOI
A novel tool for the assessment of pain: validation in low back pain.
Joachim Scholz,Richard J. Mannion,Daniela E. Hord,Robert S. Griffin,Bhupendra Rawal,Hui Zheng,Daniel Scoffings,Amanda Phillips,Jianli Guo,R. J. Laing,Salahadin Abdi,Isabelle Decosterd,Clifford J. Woolf +12 more
TL;DR: Joachim Scholz and colleagues develop and validate an assessment tool that distinguishes between radicular and axial low back pain.