Richard M. Weinshilboum

TL;DR: A cDNA that encodes an apparent human orthologue of a rat sulfotransferase (ST) cDNA is isolated and sequenced that has been referred to as "ST1C1"-although it was recently recommended that sulfotranferase proteins and cDNAs be abbreviated "SULT."

TL;DR: TAILOR-PCI (Tailored Antiplatelet Initiation to Lessen Outcomes due to Decreased Clopidogrel Response After Percutaneous Coronary Intervention) is a large, pragmatic, randomized trial comparing point- of-care genotype-guided antiplatelet therapy with routine care to determine whether identifying CYP2C19 loss-of-function allele patients prospectively and prescribing alternative antiplatelets therapy is beneficial.

TL;DR: A TPMT nomenclature committee was formed in 2010, and it has decided to renumber two alleles: nucleotide position 106 (G>A) from TPM t*24 to TPMt*30 and position 611 (T>C, rs79901429) fromTPMT*28 to T PMT*31.

TL;DR: A radiochemical micromethod for the determination of catechol-O-methyltransferase activity in human red blood cells (RBC) is described and an internal standard of purified rat liver COMT is added to lysates to detect possible variations in endogenous activators or inhibitors of the enzyme.

TL;DR: Experiments performed with the partially purified and separated forms confirmed that p-nitrophenol, phenol, 6-OH-melatonin and acetaminophen were substrates for both forms of platelet PST.