Richard M. Weinshilboum

TL;DR: A novel gene encoding an anastrozole transporter, SLC38A7, was identified, as well as epistatic interaction between SNPs in that gene and SNPs near ALPPL2 that influenced both the expression of the transporter and anast rozole plasma concentrations.

TL;DR: In this paper, the authors developed an in vitro model of chronic stress using human induced pluripotent stem cell (iPSC)-derived astrocytes treated with cortisol for 7 days.

TL;DR: In this paper, the authors used probabilistic graphical models (PGMs) to identify specific depressive symptoms and thresholds of improvement that were predictive of antidepressant response by 4 weeks for a patient to achieve remission, response, or nonresponse by 8 weeks.

TL;DR: Among the identified small set of genes associated with reduced breast cancer incidence, laboratory experiments on one of the genes, CDC42, showed that its downregulation by metformin inhibited cancer cell migration and proliferation, thus validating the ability of machine learning approaches to identify biologically relevant candidates for laboratory experiments.

TL;DR: In this article, the authors investigated the role of TCF7L2 in the central nervous system (CNS) and its possible role in the effect of body mass index (BMI) interaction.