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Richard S. Spielman

Researcher at University of Pennsylvania

Publications -  130
Citations -  16030

Richard S. Spielman is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Gene & Allele. The author has an hindex of 48, co-authored 121 publications receiving 15707 citations. Previous affiliations of Richard S. Spielman include April.

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Gene dosage and susceptibility to insulin‐dependent diabetes

TL;DR: The results strongly support the hypothesis that, closely linked to the HLA region, there is a locus (S) for susceptibility to IDDM.
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Assessment of 115 Candidate Genes for Diabetic Nephropathy by Transmission/Disequilibrium Test

TL;DR: The transmission/disequilibrium test (TDT) was used to analyze 115 candidate genes for linkage and association with diabetic nephropathy to provide modest support for a number of candidate genes previously studied by others.
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Effects of cis and trans genetic ancestry on gene expression in African Americans

TL;DR: The results provide strong evidence of a genetic contribution to expression differences between European and African populations, validating previous findings and estimating that 12±3% of all heritable variation in human gene expression is due to cis variants.
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Gene Expression and Genetic Variation in Response to Endoplasmic Reticulum Stress in Human Cells

TL;DR: To identify the underlying changes in gene expression in response to ER stress, induced ER stress in human B cells and then measured gene expression at ten time points and rediscovered genes that were known to play a role in the ER-stress response and uncovered several thousand genes that are not known to be involved.
Journal Article

Variability in T cell receptor V beta gene usage in human peripheral blood lymphocytes. Studies of identical twins, siblings, and insulin-dependent diabetes mellitus patients.

TL;DR: The results suggest that the repertoire of peripheral T cell specificities present in different individuals in human populations varies dramatically because of the effects of multiple factors, including TCR germ-line polymorphism.