R
Richard S. Spielman
Researcher at University of Pennsylvania
Publications - 130
Citations - 16030
Richard S. Spielman is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Gene & Allele. The author has an hindex of 48, co-authored 121 publications receiving 15707 citations. Previous affiliations of Richard S. Spielman include April.
Papers
More filters
Journal ArticleDOI
Gene dosage and susceptibility to insulin‐dependent diabetes
TL;DR: The results strongly support the hypothesis that, closely linked to the HLA region, there is a locus (S) for susceptibility to IDDM.
Journal ArticleDOI
Assessment of 115 Candidate Genes for Diabetic Nephropathy by Transmission/Disequilibrium Test
TL;DR: The transmission/disequilibrium test (TDT) was used to analyze 115 candidate genes for linkage and association with diabetic nephropathy to provide modest support for a number of candidate genes previously studied by others.
Journal ArticleDOI
Effects of cis and trans genetic ancestry on gene expression in African Americans
Alkes L. Price,Nick Patterson,Dustin C. Hancks,Simon Myers,David Reich,David Reich,Vivian G. Cheung,Vivian G. Cheung,Richard S. Spielman +8 more
TL;DR: The results provide strong evidence of a genetic contribution to expression differences between European and African populations, validating previous findings and estimating that 12±3% of all heritable variation in human gene expression is due to cis variants.
Journal ArticleDOI
Gene Expression and Genetic Variation in Response to Endoplasmic Reticulum Stress in Human Cells
Beth A. Dombroski,Renuka R. Nayak,Kathryn G. Ewens,Wendy Ankener,Vivian G. Cheung,Vivian G. Cheung,Richard S. Spielman +6 more
TL;DR: To identify the underlying changes in gene expression in response to ER stress, induced ER stress in human B cells and then measured gene expression at ten time points and rediscovered genes that were known to play a role in the ER-stress response and uncovered several thousand genes that are not known to be involved.
Journal Article
Variability in T cell receptor V beta gene usage in human peripheral blood lymphocytes. Studies of identical twins, siblings, and insulin-dependent diabetes mellitus patients.
TL;DR: The results suggest that the repertoire of peripheral T cell specificities present in different individuals in human populations varies dramatically because of the effects of multiple factors, including TCR germ-line polymorphism.