R
Rikke Birgitte Lyngaa
Researcher at Technical University of Denmark
Publications - 19
Citations - 3413
Rikke Birgitte Lyngaa is an academic researcher from Technical University of Denmark. The author has contributed to research in topics: Antigen & Epitope. The author has an hindex of 14, co-authored 19 publications receiving 2736 citations. Previous affiliations of Rikke Birgitte Lyngaa include Herlev Hospital & National Veterinary Institute.
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Journal ArticleDOI
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
Nicholas McGranahan,Nicholas McGranahan,Andrew Furness,Rachel Rosenthal,Sofie Ramskov,Rikke Birgitte Lyngaa,Sunil Kumar Saini,Mariam Jamal-Hanjani,Gareth A. Wilson,Nicolai Juul Birkbak,Crispin T. Hiley,Thomas B.K. Watkins,Seema Shafi,Nirupa Murugaesu,Richard Mitter,Ayse U. Akarca,Joseph Linares,Teresa Marafioti,Jake Y. Henry,Eliezer M. Van Allen,Eliezer M. Van Allen,Diana Miao,Diana Miao,Bastian Schilling,Dirk Schadendorf,Levi A. Garraway,Levi A. Garraway,Vladimir Makarov,Naiyer A. Rizvi,Alexandra Snyder,Alexandra Snyder,Matthew D. Hellmann,Matthew D. Hellmann,Taha Merghoub,Jedd D. Wolchok,Jedd D. Wolchok,Sachet A. Shukla,Sachet A. Shukla,Catherine J. Wu,Karl S. Peggs,Timothy A. Chan,Sine Reker Hadrup,Sergio A. Quezada,Charles Swanton +43 more
TL;DR: A relationship between clonal neoantigen burden and overall survival in primary lung adenocarcinomas and the impact of neoantigens intratumor heterogeneity (ITH) on antitumor immunity is demonstrated.
Journal ArticleDOI
Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes
Amalie Kai Bentzen,Andrea Marion Marquard,Rikke Birgitte Lyngaa,Sunil Kumar Saini,Sofie Ramskov,Marco Donia,Lina Such,Andrew Furness,Nicholas McGranahan,Rachel Rosenthal,Per thor Straten,Zoltan Szallasi,Inge Marie Svane,Charles Swanton,Sergio A. Quezada,Søren Nyboe Jakobsen,Aron Charles Eklund,Sine Reker Hadrup +17 more
TL;DR: The authors used peptide-major histocompatibility complex (MHC) multimers labeled with individual DNA barcodes to screen >1,000 peptide specificities in a single sample, and detect low-frequency CD8 T cells specific for virus- or cancer-restricted antigens.
Journal ArticleDOI
Dissection of T cell antigen specificity in human melanoma
Rikke Sick Andersen,Charlotte Albaek Thrue,Niels Junker,Rikke Birgitte Lyngaa,Marco Donia,Eva Ellebaek,Inge Marie Svane,Ton N. Schumacher,Per thor Straten,Sine Reker Hadrup +9 more
TL;DR: The findings provide an initial definition of T-cell populations contributing to tumor recognition in Tils although the specificity of many tumor-reactive TILs remains undefined.
Journal ArticleDOI
Parallel detection of antigen-specific T cell responses by combinatorial encoding of MHC multimers
Rikke Sick Andersen,Pia Kvistborg,Thomas Mørch Frøsig,Thomas Mørch Frøsig,Natasja Wulff Pedersen,Rikke Birgitte Lyngaa,Arnold H. Bakker,Chengyi Jenny Shu,Per thor Straten,Ton N. Schumacher,Sine Reker Hadrup,Sine Reker Hadrup +11 more
TL;DR: In this article, a method for high-throughput parallel detection of antigen-specific T cells by combinatorial encoding of peptide-MHC multimers is presented, which can be used for T cell epitope mapping, and also for the monitoring of CD8(+) immune responses during cancer and infectious disease or after immunotherapy.
Parallel detection of antigen-specific T cell responses by combinatorial encoding of MHC
Pia Kvistborg,Thomas Mørch Frøsig,Natasja Wulff Pedersen,Rikke Birgitte Lyngaa,Arnold H. Bakker,Chengyi Jenny Shu,Per thor Straten,Ton N. Schumacher,Sine Reker Hadrup +8 more
TL;DR: A method for high-throughput parallel detection of antigen-specific T cells by combinatorial encoding of MHC multimers, which can be used for T cell epitope mapping, and also for the monitoring of CD8+ immune responses during cancer and infectious disease or after immunotherapy.