Rikke Kaae Kirk

TL;DR: Results give important new insight into the molecular mode of action of GLP-1 analogs by identifying the exact cellular localization of GLp-1R.

TL;DR: Results suggest that the transient absorption enhancement offered by SNAC coformulation may help develop effective oral peptide–based therapies, and have implications for understanding how highly efficacious and specific therapeutic peptides could be transformed from injectable to tablet-based oral therapies.

TL;DR: Inspired by the leopard tortoise’s ability to passively reorient, an ingestible self-orienting millimeter-scale applicator (SOMA) is developed that autonomously positions itself to engage with GI tissue and delivers active pharmaceutical ingredient plasma levels comparable to those achieved with subcutaneous millipost administration.

TL;DR: The killed sows had significantly lower body condition compared with spontaneously dead sows and the first two parities and the time around farrowing were associated with the highest mortality in both groups.

TL;DR: An orally dosed liquid auto-injector capable of delivering up to 4-mg doses of a bioavailable drug with the rapid pharmacokinetics of an injection, reaching an absolute bioavailability of up to 80% and a maximum plasma drug concentration within 30 min after dosing is presented.