Csaba Fekete

TL;DR: This work has generated conditional mutants in which brain-derived neurotrophic factor has been eliminated from the brain after birth through the use of the cre-loxP recombination system, and these mutants were hyperactive after exposure to stressors and had higher levels of anxiety when evaluated in the light/dark exploration test.

TL;DR: The data suggest that α-MSH has an important role in the activation of pro-TRH gene expression in hypophysiotropic neurons via either a mono- and/or multisynaptic pathway to the PVN, but factors in addition to α- MSH also contribute to the mechanism by which leptin administration restores thyroid hormone levels to normal in fasted animals.

TL;DR: Evidence that an anatomically separate population of nonhypophysiostropic TRH neurons in the anterior parvocellular subdivision of the PVN is integrated into the leptin regulatory control system by the same arcuate nucleus neuronal populations that innervate hypophysiotropicTRH neurons, raises the possibility that anterior parVOcellular TRH neuron may be involved.

TL;DR: It is shown that POMC-specific disruption of Pten resulted in hyperphagia and sexually dimorphic diet-sensitive obesity, which indicates that PIP3-mediated signals are critical regulators of the melanocortin system via modulation of KATP channels.

TL;DR: An intact cannabinoid signaling pathway is necessary for the stimulatory effects of gh Relin on AMPK activity and food intake, and for the inhibitory effect of ghrelin on paraventricular neurons.