R
Rinho Kim
Researcher at University of Pennsylvania
Publications - 4
Citations - 271
Rinho Kim is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Epigenetics & Epigenomics. The author has an hindex of 3, co-authored 3 publications receiving 228 citations.
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Journal ArticleDOI
DNA methylation is required for the control of stem cell differentiation in the small intestine
Karyn L. Sheaffer,Rinho Kim,Reina Aoki,Ellen N. Elliott,Jonathan Schug,Lukas Burger,Lukas Burger,Dirk Schübeler,Dirk Schübeler,Klaus H. Kaestner +9 more
TL;DR: Determination of the base-resolution DNA methylome in intestinal stem cells and their differentiated descendants shows that DNA methylation is dynamic at enhancers, which are often associated with genes important for both stem cell maintenance and differentiation.
Journal ArticleDOI
Epigenetic regulation of intestinal stem cells by Tet1-mediated DNA hydroxymethylation.
TL;DR: In this article, the authors examined the role of TET hydroxylases in the development of the intestinal stem cells and showed that Tet1-mediated DNA hydroxymethylation plays a critical role in the epigenetic regulation of the Wnt pathway in intestinal stem and progenitor cells.
Journal ArticleDOI
5-hydroxymethylcytosine represses the activity of enhancers in embryonic stem cells: a new epigenetic signature for gene regulation
TL;DR: It is suggested that 5hmC is a new epigenetic mark for silenced enhancers, and has a repressive role at specific proximal and distal regulatory regions in mESCs, and is inversely correlated with RNA polymerase II occupancy.
Journal ArticleDOI
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD
G. Günes Günsel,Thomas M. Conlon,Aicha Jeridi,Rinho Kim,Zeynep Ertüz,Niklas J. Lang,Meshal Ansari,Mariia Novikova,Dongsheng Jiang,Maximilian Strunz,Mariia Gaianova,Christine Hollauer,C. Gabriel,Ilias Angelidis,Sebastian Doll,Jeanine Pestoni,Stephanie L. Edelmann,Marlene Kohlhepp,Adrien Guillot,Kevin Baßler,Hannelore Van Eeckhoutte,Ö. Kayalar,Nur Konyalilar,Tamara Kanashova,Sophie Rodius,Carolina Ballester‐López,Carlos Mario Genes Robles,Natalia F. Smirnova,Markus Rehberg,Charu Agarwal,Ioanna Krikki,Benoit J. A. Piavaux,Stijn E. Verleden,Bart M. Vanaudenaerde,Melanie Königshoff,Gunnar Dittmar,Ken R. Bracke,Joachim L. Schultze,Henrik Watz,Oliver Eickelberg,Tobias Stoeger,Gerald Burgstaller,Frank Tacke,Vigo Heissmeyer,Yuval Rinkevich,Hasan Bayram,Herbert B. Schiller,Marcus Conrad,Robert Schneider,Ali Önder Yildirim +49 more
TL;DR: In this paper , protein arginine methyltransferase 7 (PRMT7) was shown to be associated with decreased recruitment of monocytes to the site of injury and hence less severe symptoms.