Inchan Choi

TL;DR: A cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human β cells and dramatically downregulated in islets from T2DM organ donors is identified.

TL;DR: Re-derivation of HDAC3ΔIEC mice into germ-free conditions revealed that dysregulated IEC gene expression, Paneth cell homeostasis and intestinal barrier function were largely restored in the absence of commensal bacteria.

TL;DR: The results raise the intriguing hypothesis that by collaborating with CTCF, RBPJ may participate in establishing chromatin domains and/or long-range chromatin interactions that could be propagated through cell division to maintain gene expression programs.

TL;DR: In this article, the authors examined the role of TET hydroxylases in the development of the intestinal stem cells and showed that Tet1-mediated DNA hydroxymethylation plays a critical role in the epigenetic regulation of the Wnt pathway in intestinal stem and progenitor cells.

TL;DR: It is suggested that 5hmC is a new epigenetic mark for silenced enhancers, and has a repressive role at specific proximal and distal regulatory regions in mESCs, and is inversely correlated with RNA polymerase II occupancy.