K
Kyoung-Jae Won
Researcher at University of Copenhagen
Publications - 119
Citations - 6428
Kyoung-Jae Won is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Regulation of gene expression & Transcription factor. The author has an hindex of 36, co-authored 105 publications receiving 4915 citations. Previous affiliations of Kyoung-Jae Won include University of California, San Diego & The Feinstein Institute for Medical Research.
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Journal ArticleDOI
Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation
Joyce V. Lee,Alessandro Carrer,Supriya Shah,Nathaniel W. Snyder,Shuanzeng Wei,Sriram Venneti,Andrew J. Worth,Zuo-Fei Yuan,Hee-Woong Lim,Shichong Liu,Ellen Jackson,Nicole M. Aiello,Naomi B. Haas,Timothy R. Rebbeck,Alexander R. Judkins,Kyoung-Jae Won,Lewis A. Chodosh,Benjamin A. Garcia,Ben Z. Stanger,Michael Feldman,Ian A. Blair,Kathryn E. Wellen +21 more
TL;DR: It is demonstrated that acetyl-CoA is dynamically regulated by glucose availability in cancer cells and that the ratio of acetyl -CoA:coenzyme A within the nucleus modulates global histone acetylation levels.
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AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy
Hijai R. Shin,Hyun-Kyung Kim,Sungryong Oh,Jun Gi Lee,Minjung Kee,Hyun-Jeong Ko,Mi-Na Kweon,Kyoung-Jae Won,Sung Hee Baek +8 more
TL;DR: It is demonstrated that CARM1-dependent histone arginine methylation is a crucial nuclear event in autophagy, and a new signalling axis of AMPK–SKP2–CARM1 is identified in the regulation ofAutophagy induction after nutrient starvation.
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Single-cell transcriptomics of the human endocrine pancreas
Yue J. Wang,Jonathan Schug,Kyoung-Jae Won,Chengyang Liu,Ali Naji,Dana Avrahami,Maria L. Golson,Klaus H. Kaestner +7 more
TL;DR: It is shown that α- and β-cells from children exhibit less well-defined gene signatures than those in adults, and a robust computational biology framework for cell type annotation is developed, which provides a stepping stone for future explorations of cellular heterogeneity in pancreatic endocrine cells.
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EBF2 Determines and Maintains Brown Adipocyte Identity
Sona Rajakumari,Jun Wu,Jeff Ishibashi,Hee-Woong Lim,An Hoa Giang,Kyoung-Jae Won,Randall R. Reed,Patrick Seale +7 more
TL;DR: It is shown that early B cell factor-2 (Ebf2) regulates Pparγ binding activity to determine brown versus white adipocyte identity and is identified as a key transcriptional regulator of brown fat cell fate and function.
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Prdm16 Is Required for the Maintenance of Brown Adipocyte Identity and Function in Adult Mice
Matthew J. Harms,Jeff Ishibashi,Wenshan Wang,Hee-Woong Lim,Susumu Goyama,Tomohiko Sato,Mineo Kurokawa,Kyoung-Jae Won,Patrick Seale +8 more
TL;DR: Results show that Prdm16 and Prdm3 control postnatal BAT identity and function and Interestingly, the loss of brown fat identity due to ablation of PrDM16 was accelerated by concurrent deletion of the closely related PrDM3 gene.